During 370 days 9 healthy young volunteers were exposed to antiorthostatic hypokinesia. Group A consisting of 4 subjects performed exercises similar to those regularly made by Mir crewmembers and Group B consisting of 5 subjects did not exercise for 120 days and then performed experimental exercise regimens. It was demonstrated that the health status of men long exposed to head-down tilting can be controlled with the aid of various countermeasures. As a result of the exposure, orthostatic and exercise tolerance diminished. In view of the fact that the changes observed were more pronounced in the Group B subjects, it can be concluded that the countermeasures used were more effective in Group A subjects.

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