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Non-invasive Serological Monitoring for Crohn's Disease Postoperative Recurrence.
J Crohns Colitis
December 2022
Department of Gastroenterology, St Vincent's Hospital and Department of Medicine, University of Melbourne, Melbourne, VIC, Australia.
Introduction: Crohn's disease recurs after intestinal resection. This study evaluated accuracy of a new blood test, the Endoscopic Healing Index [EHI], in monitoring for disease recurrence.
Methods: Patients enrolled in the prospective POCER study [NCT00989560] underwent a postoperative colonoscopic assessment at 6 [2/3 of patients] and 18 months [all patients] following bowel resection, using the Rutgeerts score [recurrence ≥i2].
Endoscopic Prediction of Crohn's Disease Postoperative Recurrence.
Inflamm Bowel Dis
May 2022
Department of Gastroenterology, St. Vincent's Hospital and Department of Medicine, The University of Melbourne, Melbourne, Australia.
Article Synopsis
- The study investigates the link between early endoscopic findings after Crohn's disease intestinal surgery and the future disease course, utilizing the Rutgeerts score as a key indicator of endoscopic recurrence.
- Conducted as part of a randomized trial, 85 patients underwent colonoscopies at 6 and 18 months post-surgery, with specific treatment adjustments made based on early endoscopic results.
- The research found that a combination of ulcer depth and circumference at the anastomosis at the 6-month mark could predict endoscopic recurrence at 18 months, leading to the development of the POCER index to assess disease progression risk.
Luminal microbiota related to Crohn's disease recurrence after surgery.
Gut Microbes
November 2020
Cambridge Baker Systems Genomics Initiative, Baker Heart and Diabetes Institute, Melbourne, Australia and Cambridge Baker Systems Genomics Initiative, Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK.
Background: Microbial factors are likely to be involved in the recurrence of Crohn's disease (CD) after bowel resection. We investigated the luminal microbiota before and longitudinally after surgery, in relation to disease recurrence, using 16S metagenomic techniques.
Methods: In the prospective Post-Operative Crohn's Endoscopic Recurrence (POCER) study, fecal samples were obtained before surgery and 6, 12, and 18 months after surgery from 130 CD patients.
Visceral adiposity predicts post-operative Crohn's disease recurrence.
Aliment Pharmacol Ther
May 2017
Department of Gastroenterology, St Vincent's Hospital, Melbourne, Vic., Australia.
Background: Excessive visceral adipose tissue has been associated with poorer outcomes in patients with inflammatory bowel disease.
Aim: To determine whether body composition is associated with outcome in a prospective study of post-operative Crohn's disease patients.
Methods: The POCER study evaluated management strategies for prevention of post-operative Crohn's disease recurrence; subjects were enrolled after resection of all macroscopic Crohn's disease and were randomised to early endoscopy and possible treatment escalation, or standard care.
Cost-effectiveness of Crohn's disease post-operative care.
World J Gastroenterol
April 2016
Emily K Wright, Michael A Kamm, Peter Dr Cruz, Amy L Hamilton, Kathryn J Ritchie, Sally J Bell, Steven J Brown, William R Connell, Paul V Desmond, Department of Gastroenterology, St Vincent's Hospital, University of Melbourne, Fitzroy VIC 3065, Melbourne, Australia.
Aim: To define the cost-effectiveness of strategies, including endoscopy and immunosuppression, to prevent endoscopic recurrence of Crohn's disease following intestinal resection.
Methods: In the "POCER" study patients undergoing intestinal resection were treated with post-operative drug therapy. Two thirds were randomized to active care (6 mo colonoscopy and drug intensification for endoscopic recurrence) and one third to drug therapy without early endoscopy.
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