Upregulation of Thrombospondin 1 Expression in Synovial Tissues and Plasma of Rheumatoid Arthritis: Role of Transforming Growth Factor-β1 toward Fibroblast-like Synovial Cells.

Takahisa Suzuki Naoki Iwamoto Satoshi Yamasaki Ayako Nishino Yoshikazu Nakashima Yoshiro Horai Shin-Ya Kawashiri Kunihiro Ichinose Kazuhiko Arima Mami Tamai Hideki Nakamura Tomoki Origuchi Chikara Miyamoto Makoto Osaki Kaname Ohyama Naotaka Kuroda Atsushi Kawakami

J Rheumatol

From the Department of Immunology and Rheumatology, Department of Public Health, Department of Health Sciences, Department of Orthopedic Surgery, and Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki; and Department of Clinical Immunology and Rheumatology, Hiroshima University, Hiroshima, Japan.T. Suzuki, MD; N. Iwamoto, MD, PhD, Assistant Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S. Yamasaki, MD, PhD, Department of Clinical Immunology and Rheumatology, Hiroshima University; A. Nishino, MD; Y. Nakashima, MD; Y. Horai, MD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; S.Y. Kawashiri, MD, PhD, Department of Immunology and Rheumatology, and Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; K. Ichinose, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; K. Arima, MD, PhD, Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences; M. Tamai, MD, PhD; H. Nakamura, MD, PhD, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences; T. Origuchi, MD, PhD, Professor, Department of Health Sciences, Nagasaki University Graduate School of Biomedical Sciences; C. Miyamoto, MD, PhD; M. Osaki, MD, PhD, Professor, Department of Orthopedic Surgery, Nagasaki University Graduate School of Biomedical Sciences; K. Ohyama, PhD; N. Kuroda, PhD, Professor, Department of Environmental and Pharmaceutical Sciences, Nagasaki University Graduate School of Biomedical Sciences; A. Kawakami, MD, PhD, Professor, Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences.

Published: June 2015

Objective: To investigate the role of thrombospondin 1 (TSP-1) in RA.

Methods: Expression of TSP-1 in synovial tissues was determined by immunohistochemistry. Expression of TSP-1 in rheumatoid fibroblast-like synovial cells (FLS) was investigated by quantitative real-time PCR and ELISA. Correlations among the plasma TSP-1 and other variables in patients with RA were examined.

Results: Expression of TSP-1 was increased in rheumatoid synovial tissues. Transforming growth factor-β1 (TGF-β1) clearly increased TSP-1 expression in FLS on both mRNA and protein levels. Changes in plasma TSP-1 were associated with those in 28-joint Disease Activity Score-erythrocyte sedimentation rate and plasma TGF-β1.

Conclusion: TSP-1 might be critically involved in the disease process of RA through the TGF-β1/TSP-1 axis.

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http://dx.doi.org/10.3899/jrheum.141292	DOI Listing

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