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Disseminated nontuberculous mycobacterial infection in the context of interferon-gamma autoantibody syndrome: A case report and review of the literature.
Eur J Microbiol Immunol (Bp)
January 2025
1Department of Infectious Diseases, John Hunter Hospital, New Lambton Heights, NSW 2305, Australia.
Interferon-gamma (IFN-γ) autoantibody syndrome is an emerging clinical entity that has been associated with disseminated non-tuberculous mycobacterial infection (dNTM) particularly in healthy young people, a population not previously thought to be at particular risk. A 29-year-old South-East Asian man presented with several weeks of fever, cough, lymphadenopathy, and constitutional symptoms while working on an international cargo ship, deteriorating rapidly with a sepsis-like syndrome. Eventually lymph node and sputum cultures revealed a diagnosis of dNTM infection with growth of both Mycobacterium persicum and Mycobacterium abscessus.
View Article and Find Full Text PDFAdult-Onset Hemophagocytic Lymphohistiocytosis Associated With Epstein-Barr Virus, Lyme Disease, and Anaplasmosis.
Cureus
October 2024
Internal Medicine, Northwell Health, New York, USA.
Adult-onset hemophagocytic lymphohistiocytosis (HLH) is a life-threatening hyperinflammatory syndrome characterized by dysregulated immune activation. Diagnosing HLH poses significant challenges due to its nonspecific clinical presentation, which often mimics infections, malignancies, and autoimmune diseases. Early recognition and prompt initiation of immunosuppressive therapy are crucial, as delayed treatment is associated with a high risk of mortality.
View Article and Find Full Text PDFUsefulness of Thymus and Activation-Regulated Chemokine for the Diagnosis of Food Protein-Induced Enterocolitis Syndrome with Sepsis-Like Symptoms in a Pediatric Patient with Trisomy 13.
Indian J Pediatr
January 2025
Department of Pediatrics, Dokkyo Medical University, 880 Kitakobayashi, Mibu, Tochigi, 321-0293, Shimotsuga, Japan.
A Challenging Case of Recurrent Fever.
Cureus
August 2024
Pediatrics, Hospital Central do Funchal, Serviço de Saúde da Região Autónoma da Madeira, Entidade Pública Empresarial da Região Autónoma da Madeira (SESARAM, EPERAM), Funchal, PRT.
Syndrome of undifferentiated recurrent fever (SURF) includes heterogeneous episodes of systemic inflammation without documented infection, without response to antibiotherapy, and characterized by a paucity of specific clinical or molecular criteria. Colchicine is an effective treatment with an impact on morbimortality. We describe a case of a previously healthy one-year-old male, with consanguineous ancestry, admitted four times due to recurrent fever, associated with nonspecific symptoms and an increase of inflammatory markers in a sepsis-like pattern.
View Article and Find Full Text PDFBacteria-Associated Cytokine Storm Syndrome.
Adv Exp Med Biol
August 2024
University of Alabama at Birmingham, Department of Pediatrics, Birmingham, AL, USA.
While viruses are considered the most common infectious triggers for cytokine storm syndromes (CSS), a growing list of bacterial pathogens, particularly intracellular organisms, have been frequently reported to be associated with this syndrome. Both familial and sporadic cases of CSS are often precipitated by acute infections. It is also important to note that an underlying precipitating infection might not be clinically obvious as the CSS clinical picture can mimic an infectious process or an overwhelming septicemia.
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