Synthesis of Cinnolin-3(2H)-one Derivatives from Rh-Catalyzed Reaction of Azobenzenes with Diazotized Meldrum's Acid.

Org Lett

National Creative Research Initiative Center for Catalytic Organic Reactions, Department of Chemistry, Kangwon National University, Chuncheon 200-701, Republic of Korea.

Published: May 2015

A synthetic method of a wide range of cinnolin-3(2H)-one derivatives is developed from the reaction of symmetrical as well as unsymmetrical azobenzenes with diazotized Meldrum's acid via Rh-catalyzed C-H alkylation followed by cyclization.

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http://dx.doi.org/10.1021/acs.orglett.5b01052DOI Listing

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