Purpose: The objective of this study was to evaluate the influence of the TNF-α rs1800629 polymorphism on the risk of cervical cancer.
Methods: A comprehensive search of EMBASE, PubMed, Wanfang database and China National Knowledge Infrastructure (CNKI) was conducted and the papers published were retrieved. The fixed effects or random effects model was appropriately used to calculate the odds ratio (OR) along with 95% confidence interval (CI).
Results: Data from sixteen articles containing nineteen studies were summarized in this meta-analysis. In general, we observed a marginal association between the TNF-α rs1800629 polymorphism and cervical cancer risk under the AA + AG vs. GG comparison model (OR=1.17, 95% CI=1.00-1.38, P=0.019 for heterogeneity). Interestingly, significantly increased risk was observed in the allele model (A vs. G: OR=1.19, 95% CI=1.02-1.38, P=0.006 for heterogeneity). In the stratified analysis by ethnicity, we found significant results in Caucasians.
Conclusions: Our results reveal that the Caucasian population may be at increased risk of developing invasive cervical cancer associated with the TNF-α rs1800629 polymorphism.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4402788 | PMC |
Publication Analysis
Top Keywords
Similar Publications
Identifying genetic susceptibility loci associated with human coronary artery disease.
PLoS One
January 2025
Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, China.
Coronary artery disease (CAD) is a multigenic condition influenced by both nature and nurture (60% to 40%). Prognosis of CAD is based on familial patterns. This study examined and analyzed the susceptibility of CAD to genetic variants in various Pakistani families.
View Article and Find Full Text PDFLack of association between common polymorphisms associated with successful aging and longevity in the population of Sardinian Blue Zone.
Sci Rep
December 2024
Dipartimento di Medicina, Chirurgia e Farmacia, University of Sassari, Viale San Pietro 43, Sassari, 07100, Italy.
More than two decades ago, in the central-eastern region of the Mediterranean island of Sardinia, a mountain area was identified where the population displays exceptional longevity, especially among men (the Longevity Blue Zone, LBZ). This community was thoroughly investigated to understand the underlying causes of the phenomenon. The present study analyzed 11 genetic markers previously associated with increased survival in several long-lived populations.
View Article and Find Full Text PDFGenetic predisposition meets cytokine imbalance: the influence of TNF-α (-308) polymorphism and TGF-β levels in pediatric acute lymphoblastic leukemia in Egypt.
BMC Cancer
December 2024
Hematology, Oncology and Bone Marrow Transplantation Unit, Pediatric Department, Faculty of Medicine, Mansoura University, Mansoura, Egypt.
Evading apoptosis fuels the aggressive nature of acute lymphoblastic leukemia (ALL). This study explored the potential roles of TNF-α, a pro-apoptotic cytokine, and TGF-β, a pro-proliferative factor, in the risk of developing ALL in Egyptian children. We investigated the TNF-α rs1800629 polymorphism and serum TGF-β levels in 100 ALL patients and 100 healthy controls.
View Article and Find Full Text PDFThe functional TNF-αG > a single-nucleotide polymorphism (rs1800629): association with the predictive indices of breast cancer carcinogenesis.
Breast Cancer Res Treat
November 2024
Mansoura University Children's Hospital, Mansoura University, Mansoura, Egypt.
Background: Compared with all other cancer types, Breast cancer (BC) among women has now exceeded them all as the primary reason for cancer worldwide. The BC represents 11.7% of all cancer cases and accounts for a predestined 2.
View Article and Find Full Text PDFGenetic Variability in Oxidative Stress, Inflammatory, and Neurodevelopmental Pathways: Impact on the Susceptibility and Course of Spinal Muscular Atrophy.
Cell Mol Neurobiol
October 2024
Institute of Biochemistry and Molecular Genetics, Faculty of Medicine, University of Ljubljana, Ljubljana, Slovenia.
Article Synopsis
- The study investigates how genetic variations in oxidative stress, inflammation, and neurodevelopment affect spinal muscular atrophy (SMA) susceptibility and clinical progression, despite the strong influence of the SMN2 gene copy number.
- Researchers analyzed genetic data from 54 SMA patients and 163 healthy controls, identifying specific polymorphisms linked to disease risk, type, symptom onset, and motor and respiratory functions.
- Notable findings include protective effects from TNF rs1800629 and BDNF rs6265 against SMA, and associations with motor scores and lung function, highlighting the complexity of SMA's genetic landscape and potential for personalized treatments.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!