Maternal predictors of RBC folate levels in an urban Canadian population.

Reprod Toxicol

Department of Obstetrics and Gynecology, McGill University Health Centre, McGill University, Montreal, Canada.

Published: June 2015

AI Article Synopsis

  • The study aimed to evaluate the factors contributing to low Red Blood Cell folate levels among pregnant women at a tertiary healthcare center.
  • It involved 350 women who filled out a questionnaire about folic acid usage and had their RBC folate levels measured, with 10% found to have suboptimal levels.
  • Key factors linked to lower folate levels were identified as being non-Caucasian, not taking folic acid supplements, and having insufficient information from healthcare providers about the importance of folate consumption.

Article Abstract

Objective: To assess factors associated with low Red Blood Cell folate (RBCf) levels in an obstetric population in a tertiary centre.

Methods: Cross-sectional study. Three hundred and fifty women completed a questionnaire detailing use of folic acid supplementation, and had their RBCf levels measured. Values ≥ 906 nmol/L were considered optimal. Factors associated with optimal RBCf were assessed, individually and in a logistic regression model.

Results: Median RBCf was 1282 nmol/L. Thirty-five women (10%) had suboptimal levels. Predictors of suboptimal RBCf were non-Caucasian ethnicity, non-consumption of folic acid supplementations, and inadequate health care provider information regarding the benefits of folic acid consumption.

Conclusion: Although, in our population, a high proportion of women achieved optimal levels of RBCf, some women remain at risk due to inadequate folate consumption. Patient and health care provider education regarding folate can still be improved, particularly in the groups identified to be at greater risk.

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http://dx.doi.org/10.1016/j.reprotox.2015.04.009DOI Listing

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