AI Article Synopsis
- A study analyzed data from 4147 MDS patients over 30 years to see if newer treatment options improved patient outcomes.
- Results showed patients diagnosed after 2002 had better survival rates (30 months) compared to those diagnosed from 1982 to 2001 (23 months).
- The survival improvement was mainly seen in high-risk MDS patients, while low-risk patients showed no significant change; better supportive care could be a factor in reduced deaths from complications.
Article Abstract
During the last years, more and more treatment modalities are available for MDS patients. Therefore, we were interested if this is reflected in an improvement of the outcome of the patients. We analyzed the survival and rate of leukemic progression of 4147 patients from the Duesseldorf MDS registry diagnosed during the last 30 years and found an improvement of survival in those patients diagnosed after 2002 (30 vs. 23 months, p<0.0001). In detail, the improvement of the prognosis was restricted to high-risk MDS patients diagnosed between 2002 and 2014 in comparison to the patient group diagnosed between 1982 and 2001 (19 vs. 13 months, p<0.001), whereas the prognosis of low-risk MDS patients did not change significantly. The improvement of survival was still measurable after exclusion of RAEB-t patients and of those, that received an allogeneic stem cell transplantation. In line with this finding, we found a lower AML progression rate in the later diagnosed group. Unfortunately, we could not identify a clear reason for this finding but rather a multifactorial cause should be assumed. As death due to bleeding complications and infections was significantly lower, an improvement of BSC may be one of the underlying causes.
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| http://dx.doi.org/10.1016/j.leukres.2015.04.001 | DOI Listing |
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