An enantioselective N-heterocyclic carbene (NHC)-catalyzed β-protonation through the orchestration of three distinct organocatalysts has been developed. This cooperative catalyst system enhances both yield and selectivity, compared to only the NHC-catalyzed process. This new method allows for the efficient conversion of a large scope of aryl-oxobutenoates to highly enantioenriched succinate derivatives and demonstrates the benefits of combining different activation modes in organocatalysis.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4492478 | PMC |
| http://dx.doi.org/10.1021/jacs.5b02887 | DOI Listing |
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