AI Article Synopsis
- The study investigates the effectiveness and safety of low-dose (2,500 U) versus high-dose (5,000 U) heparin during transradial coronary angiography to reduce radial artery occlusion.
- At day 7, radial artery occlusion rates were similar between both groups (5.9% LD vs 5.4% HD), indicating no significant difference in efficacy (p = 0.83).
- However, the low-dose group experienced significantly less bleeding during band deflation (6.4% vs 18.3%, p < 0.001), suggesting that lower heparin doses minimize bleeding risks without compromising artery patency.
Article Abstract
Objectives: Although heparin is highly effective in reducing the rate of radial artery occlusion after transradial catheterization, the optimal heparin dose is still controversial. The aim of this study was to evaluate the efficacy and safety of two different heparin doses during transradial coronary angiography.
Methods: 490 consecutive patients undergoing transradial coronary angiography were prospectively enrolled into this double-blind randomized trial. A total of 202 patients enrolled in the low-dose (LD; 2,500 U of heparin) group and 202 patients enrolled in the high-dose (HD; 5,000 U of heparin) group were included in the final analysis. The primary endpoint of the study was radial artery occlusion. Bleeding and hematomas were the secondary outcome measures.
Results: At day 7, radial artery occlusion occurred in 5.9% of the patients in the LD group and in 5.4% of the patients in the HD group (p = 0.83). Bleeding during deflation of the transradial band occurred in 6.4% of the patients in the LD group and in 18.3% of the patients in the HD group; the difference was statistically significant (p < 0.001). Higher-dose heparin was found to be an independent predictor of bleeding (p = 0.007).
Conclusion: A lower dose of heparin (i.e. 2,500 U) decreases bleeding during transradial band deflation without an increase in radial artery occlusion.
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| http://dx.doi.org/10.1159/000377621 | DOI Listing |
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