Background: In patients with Parkinson's disease (PD) we aimed at differentiating the relation between selective visual attention, deficits of programming and dynamics of saccadic eye movements while searching for a target and hand-reaction time as well as hand-movement time. Visual attention is crucial for concentrating selectively on one aspect of the visual field while ignoring other aspects. Eye movements are anatomically and functionally related to mechanisms of visual attention. Saccadic dysfunction might confound selective visual attention in PD.
Methods: We studied visual selective attention in 22 medicated PD patients (clinical ON status, mild to moderate disease severity) and 22 age matched controls. We looked for possible interferences through oculomotor deficits. Two tasks were compared: free viewing of photographs and time optimal visual search of a hidden target. Visual search times (VST), task related dynamics of saccades, and hand-reaction and hand-movement times were analyzed.
Results: In the free viewing task mild to moderately affected PD patients did not differ statistically from healthy subjects with respect to saccade dynamics. However, patients differed significantly from healthy subjects in the time optimal visual search task with 25% lower rates of successful searches. Hand movement reaction time did not differ in both groups, whereas hand movement execution time was significantly prolonged in PD patients.
Conclusion: Saccadic oculomotor control and hand movement reaction times were intact, whereas in our less severely affected treated PD patients, visual selective attention was not. The highly reduced successful search rate might be related to disturbed programming and delayed execution of saccades during time optimal visual search due to decreased execution of serial-order sequential generation of saccades.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1159/000381335 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Breast cancer classification based on breast tissue structures using the Jigsaw puzzle task in self-supervised learning.
Radiol Phys Technol
January 2025
Department of Diagnostic Imaging, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi, 980-8575, Japan.
Self-supervised learning (SSL) has gained attention in the medical field as a deep learning approach utilizing unlabeled data. The Jigsaw puzzle task in SSL enables models to learn both features of images and the positional relationships within images. In breast cancer diagnosis, radiologists evaluate not only lesion-specific features but also the surrounding breast structures.
View Article and Find Full Text PDFPersistent effects of salience in visual working memory: Limits of cue-driven guidance.
J Exp Psychol Hum Percept Perform
January 2025
Faculte de Psychologie et des Sciences de l'Education, Universite de Geneve.
Visual working memory (VWM) is a core cognitive system enabling us to select and briefly store relevant visual information. We recently observed that more salient items were recalled more precisely from VWM and demonstrated that these effects of salience resisted manipulations of reward, probability, and selection history. Here, we investigated whether and how salience interacts with shifts of attention induced by pre- and retrocueing.
View Article and Find Full Text PDFAperiodic Pupil Fluctuations at Rest Predict Orienting of Visual Attention.
Psychophysiology
January 2025
Department of Psychology, Hangzhou Normal University, Hangzhou, Zhejiang, China.
The aperiodic exponent of the power spectrum of signals in several neuroimaging modalities has been found to be related to the excitation/inhibition balance of the neural system. Leveraging the rich temporal dynamics of resting-state pupil fluctuations, the present study investigated the association between the aperiodic exponent of pupil fluctuations and the neural excitation/inhibition balance in attentional processing. In separate phases, we recorded participants' pupil size during resting state and assessed their attentional orienting using the Posner cueing tasks with different cue validities (i.
View Article and Find Full Text PDFResearch trends and focus of prosthetic joint infections from 2013 to 2023: bibliometric and visualization studies.
Front Microbiol
December 2024
Department of Orthopedics, Affiliated Hospital of Shandong Traditional Chinese Medicine University, Jinan, China.
Background: Postoperative infections in artificial joints provide considerable difficulties in the field of orthopedics, especially after joint replacement procedures. These infections rank among the most severe postoperative consequences, frequently leading to treatment ineffectiveness and reduced quality of life for surgery patients. Consequently, it is crucial to acquire knowledge about worldwide research trends in this area in order to educate clinical practices and improve therapeutic techniques.
View Article and Find Full Text PDFMapping the current trends and hotspots of extracellular vesicles in Alzheimer's disease: a bibliometric analysis.
Front Aging Neurosci
December 2024
Department of Neurology, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China.
Background: Extracellular vesicles (EVs) have garnered significant attention in Alzheimer's disease (AD) research over the past decade, largely due to their potential in diagnostics and therapeutics. Although the investigation of EVs in AD is a relatively recent endeavor, a comprehensive bibliometric analysis of this rapidly growing field has yet to be conducted.
Methods: This study aims to elucidate and synthesize the relationship between EVs and AD, offering critical insights to guide future research and expand therapeutic possibilities.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!