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Amount of hepatic fat predicts cardiovascular risk independent of insulin resistance among Hispanic-American adolescents. | LitMetric

Amount of hepatic fat predicts cardiovascular risk independent of insulin resistance among Hispanic-American adolescents.

Lipids Health Dis

Division of Pediatric Gastroenterology, Hepatology and Nutrition, School of Medicine, Emory University, Atlanta, GA, 30322, USA.

Published: May 2015

AI Article Synopsis

  • Nonalcoholic fatty liver disease (NAFLD) affects over one-third of obese children in the U.S., leading to serious cardiovascular risks even in adolescents.
  • A study of 50 overweight Hispanic-American adolescents found significant correlations between increased liver fat and unfavorable lipid profiles, such as higher plasma triglycerides and changes in lipoprotein concentrations.
  • The research suggests that more fat in the liver may heighten cardiovascular risk, indicating the need for future studies to track lipid changes in NAFLD children and explore the potential benefits of reducing liver fat.

Article Abstract

Background: Nonalcoholic fatty liver disease (NAFLD) has emerged as the major pediatric chronic liver disease, and it is estimated to affect more than one third of obese children in the U.S. Cardiovascular complications are a leading cause of increased mortality in adults with NAFLD and many adolescents with NAFLD already manifest signs of subclinical atherosclerosis including increased carotid intima-media thickness.

Methods: Volume of intrahepatic fat was assessed in 50 Hispanic-American, overweight adolescents, using Magnetic Resonance Spectroscopy. Lipoprotein compositions were measured using Nuclear Magnetic Resonance.

Results: Plasma triglycerides (TG) (p=0.003), TG/HDL ratio (p=0.006), TG/apoB ratio (p=0.011), large VLDL concentration (p=0.019), VLDL particle size (p=0.012), as well as small dense LDL concentration (p=0.026) progressively increased across higher levels of hepatic fat severity, while large HDL concentration progressively declined (p=0.043). This pattern of associations remained even after controlling for gender, BMI, visceral fat, and insulin resistance.

Conclusions: Our findings suggest that increased hepatic fat is strongly associated with peripheral dyslipidemia and the amount of fat in the liver may influence cardiovascular risk. Further studies are needed to longitudinally monitor dyslipidemia in children with NAFLD and to examine whether the reduction of hepatic fat would attenuate their long-term CVD risk.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4426173PMC
http://dx.doi.org/10.1186/s12944-015-0038-xDOI Listing

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