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Mechanistic understanding of pH as a driving force in cancer therapeutics.
J Mater Chem B
January 2025
Department of Forensic Science, School for Bio Engineering and Bio Sciences, Lovely Professional University, Phagwara, Punjab, India.
The development of pH-directed nanoparticles for tumor targeting represents a significant advancement in cancer biology and therapeutic strategies. These innovative materials have the ability to interact with the unique acidic microenvironment of tumors. They enhance drug delivery, increase therapeutic efficacy, and reduce systemic toxicity.
View Article and Find Full Text PDFFurther explorations into the complexities of femininity and masculinity.
Int J Psychoanal
December 2024
Société Psychanalytique de Recherche et de Formation, Paris, France.
This text explores Dana Birksted-Breen's notions of penis-as-link and negative and positive femininity, rooted in primitive mental and bodily states, in a dialogue between the manifestations of the biological body and their interpretation by the psyche in the construction of a sexed bodily mind. When the capacities for introjection have been impaired from an early stage, there is a great difficulty in representing and relating to a receptive internal space, hence to one's femininity, be it for a girl or a boy. This capacity for introjection in its relation to femininity plays a great part in the analytic capacity to display one's bodily receiver instrument as a sounding board for the analysand's unconscious.
View Article and Find Full Text PDFBiologic Therapies for Chronic Obstructive Pulmonary Disease: A Systematic Review and Network Meta-Analysis of Randomized Controlled Trials.
COPD
December 2025
Division of Respirology, Department of Medicine, McMaster University, Hamilton, ON, Canada.
Background: Despite limited breakthroughs in COPD pharmacotherapy, recent trials have shown promising results for biologics in COPD patients. However, robust evidence synthesis in this area is currently lacking.
Methods: We conducted a systematic review of MEDLINE, EMBASE, and Cochrane CENTRAL from inception to July 17, 2024, to identify randomized trials of biologic medications in patients with COPD.
Surface immobilization of single atoms on heteroatom-doped carbon nanospheres through phenolic-mediated interfacial anchoring for highly efficient biocatalysis.
Chem Sci
January 2025
BMI Center for Biomass Materials and Nanointerfaces, National Engineering Laboratory for Clean Technology of Leather Manufacture, Ministry of Education Key Laboratory of Leather Chemistry and Engineering, College of Biomass Science and Engineering, Sichuan University Chengdu Sichuan 610065 China
Single-atom catalysts (SACs) dispersed on support materials exhibit exceptional catalytic properties that can be fine-tuned through interactions between the single atoms and the support. However, selectively controlling the spatial location of single metal atoms while simultaneously harmonizing their coordination environment remains a significant challenge. Here, we present a phenolic-mediated interfacial anchoring (PIA) strategy to prepare SACs with Fe single atoms anchored on the surface of heteroatom-doped carbon nanospheres.
View Article and Find Full Text PDFCorrection: Strategic design of GalNAc-helical peptide ligands for efficient liver targeting.
Chem Sci
January 2025
Division of Organic Chemistry, National Institute of Health Sciences 3-25-26 Tonomachi Kawasaki Kanagawa 210-9501 Japan
[This corrects the article DOI: 10.1039/D4SC05606J.].
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