AI Article Synopsis
- The study focused on the impact of corticosteroids given during and after surgery on the risk of facial palsy following cerebellopontine angle tumor removal.
- A total of 310 patients with mainly vestibular schwannomas participated in a randomized, placebo-controlled trial across five centers from 2006 to 2010.
- Results showed that corticosteroids did not improve facial function recovery compared to placebo, regardless of tumor size, as assessed at multiple postoperative intervals.
Article Abstract
The aim of this study was to assess the effect of corticosteroids administered intra- and postoperatively on the occurrence of facial palsy after a cerebellopontine angle (CPA) tumor resection, and to investigate pre- and intraoperative prognostic factors. A multicenter, prospective, randomized, double-blind and versus-placebo study was conducted between 2006 and 2010. Three hundred and ten patients operated on for a CPA tumor (96% vestibular schwannomas, 4% miscellaneous) were included by five participating centers. The population was stratified into patients with small (≤15 mm CPA on axial MRI views) and large tumors. In each group, patients were randomized to receive corticosteroid (1 mg/kg/day i.v. methylprednisolone intraoperatively and at postoperative days 1-5) or placebo. Steroids did not affect the facial function at postoperative days 1, 8 and 30 in patients with small or large tumors as evaluated by House and Brackmann grading.
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| http://dx.doi.org/10.1159/000370191 | DOI Listing |
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