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| http://dx.doi.org/10.1186/s13054-015-0821-0 | DOI Listing |
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The effect of tonsillectomy on clinical manifestations in Familial Mediterranean fever.
Int J Pediatr Otorhinolaryngol
January 2025
Otorhinolaryngology Department, Faculty of Medicine, Menoufia University, Menoufia, Egypt; Medicine and Surgery Program, Menoufia National University, Menoufia, Egypt. Electronic address:
Purpose: Familial Mediterranean fever (FMF) is the most prevalent genetic autoinflammatory disease worldwide. There are several novel advancements in pathophysiology, genetic testing, diagnosis, comorbidities, disease-related damage, and treatment strategies. This study aimed to assess the effect of tonsillectomy on FMF disease severity and activity.
View Article and Find Full Text PDFPost-translational modifications play crucial roles in viral infections, yet many potential modifications remain unexplored in orthoflavivirus biology. Here we demonstrate that the UFMylation system, a post-translational modification system that catalyzes the transfer of UFM1 onto proteins, promotes infection by multiple orthoflaviviruses including dengue virus, Zika virus, West Nile virus, and yellow fever virus. We found that depletion of the UFMylation E3 ligase complex proteins UFL1 and UFBP1, as well as other UFMylation machinery components (UBA5, UFC1, and UFM1), significantly reduces infectious virion production for orthoflaviviruses but not the hepacivirus, hepatitis C.
View Article and Find Full Text PDFSpatial study of dengue and its association with livestock farming in Bantul Regency, Yogyakarta Province, Indonesia.
Vet World
November 2024
Department of Tropical Biology, Faculty of Biology, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Background And Aim: Dengue fever is a recurring arboviral disease. The presence of livestock and domestic animals potentially increases the risk of dengue fever in an area due to the shared habitats of vectors and humans. Therefore, this study aimed to determine the vulnerability map of dengue disease and identify the influence of livestock and domestic animals on the number of cases in Bantul Regency.
View Article and Find Full Text PDFAssociation of gross domestic product with equitable access to childhood vaccines in 195 countries: a systematic review and meta-analysis.
BMJ Glob Health
January 2025
African Vaccinology Network, Buea, Cameroon.
Introduction: Gross domestic product (GDP) has been shown to affect government spending on various budget heads including healthcare and the purchase and distribution of vaccines. This vulnerable situation has been exacerbated by the COVID-19 pandemic which disrupted and exposed the fragile nature of equitable access to vaccines for childhood immunisation globally. A systematic review and meta-analysis to assess the association of country income status and GDP with vaccination coverage of vaccines for childhood immunisation and other major infectious diseases around the globe will inform global and national policy on equity in living standards and vaccine uptake.
View Article and Find Full Text PDFBehavioral assessment to evaluate the analgesic and anti-inflammatory effects of Fagonia bruguieri var. laxa Boiss by targeting pro-inflammatory cytokines and prostaglandin pathways.
J Ethnopharmacol
January 2025
College of Pharmacy, Shenzhen Technology University, Shenzhen 518118, Guangdong, China; Department of Pharmaceutical Chemistry, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai 90112, Songkhla, Thailand; Drug Delivery System Excellence Center, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Hat Yai 90112, Songkhla, Thailand. Electronic address:
Ethnopharmacological Relevance: Fagonia bruguieri var. laxa Boiss., also known as Dhamansa or Dhamaran, is a well-known xerophyte traditionally used for managing pain, inflammation, fever, and related disease conditions.
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