Objective: To detect the expression of growth factors relating to bone reconstructions in microscrew-bone interface of implanted titanium microscrews near the extraction wounds, and to determine the influence of healing process on the growth factors.
Methods: Eight male Beagle dogs (age 18 months) were divided into experimental and control groups. Titanium microscrews were implanted near an extraction wound in the dogs in the experimental group, while the controls had implantation without extraction wounds. The dogs were sacrificed at 1, 3, 8, 12 weeks, respectively. Immunohistochemistry and in situ hybridization sections were performed to detect the expression of TGF-beta, TNF-alpha, osteocalcin (OC) protein and Cbfal mRNA.
Results: The experimental group had higher levels of expression of TGF-beta, TNF-alpha protein and Cbfa1 mRNA than the controls, with significant differences appearing at week one for TNF-alpha (P<0.05), week three for TGF-beta and TNF-alpha (P<0.05), and week eight for Cbfa1 mRNA (P<0.05). The expression of OC increased over time and reached peak at week eight (P<0.05).
Conclusion: Microscrews implanted near extraction wounds can maintain stability. Severe inflammation occurs in the early stage of healing, but does not sustain. Bone remodeling remains active over the healing process. But prolonged healing phase without force loading could weaken the remodeling.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Fiducial-marked laminectomy window for intrathecal medication administration after spinal fusion: illustrative case.
J Neurosurg Case Lessons
December 2024
Lillian S. Wells Department of Neurosurgery, University of Florida, Gainesville, Florida.
Background: Spinal muscular atrophy (SMA) is an inherited disease that leads to weakness, loss of ambulation, and progressive scoliosis in many patients, frequently requiring early spinal fusion. Nusinersen is a disease-modifying agent that improves symptoms and slows the progression of SMA but requires serial lumbar punctures for intrathecal drug delivery. Spinal fusion for scoliosis has historically been a contraindication for nusinersen therapy, as the fused spinal laminae block access to the thecal sac.
View Article and Find Full Text PDF[Comparison of polymethyl methacrylate skull implant fixation by three types of titanium fasteners].
Zh Vopr Neirokhir Im N N Burdenko
April 2024
Burdenko Neurosurgical Center, Moscow, Russia.
Objective: To evaluate mechanical strength of three methods of polymethyl methacrylate skull implant fixation in two experimental models.
Material And Methods: The first experiment was performed on a plastic model that was as close as possible to bone in structural characteristics. The second experiment was performed on a biological specimen (a ram's head).
MH cortical screws, a revolutionary orthodontic TADs design.
J Orthod Sci
October 2022
Orthodontic Department, Azadi Dental Teaching Center, General Directorate of Hawler-Ministry of Health, Erbil, Iraq.
Objective: MH cortical screws were designed to combine the advantages of thick mini-implants with the versatility of micro-screws while avoiding the disadvantages of both.
Materials And Methods: An MH cortical screw (MH is an abbreviation for the author's name) was made from titanium material. The screw has a 3 mm-long amphora-shaped shank of 2 mm thickness at its thinnest and 3 mm at its thickest part.
Customized Titanium Mesh for Guided Bone Regeneration with Autologous Bone and Xenograft.
Materials (Basel)
September 2022
Department of Oral Medicine, Faculty of Dentistry, Service of the Medical-Surgical Area of Dentistry Hospital, University of Barcelona, 08907 Barcelona, Spain.
The augmentation of the alveolar crest after the loss of one or several teeth can be carried out using different bone augmentation techniques. These techniques include bone distraction, ridge expansion, bone block grafts, etc. Guided bone regeneration is an alternative to increase the volume of the hard tissues for the subsequent placement of the implants in the optimal three-dimensional position.
View Article and Find Full Text PDF"Image to patient" equal-resolution surface registration supported by a surface scanner: analysis of algorithm efficiency for computer-aided surgery.
Int J Comput Assist Radiol Surg
February 2023
Department of Mechanics, Materials and Biomedical Engineering, Faculty of Mechanical Engineering, Wrocław University of Science and Technology, Wrocław, Poland.
Purpose: The "image to patient" registration procedure is crucial for the accuracy of surgical instrument tracking relative to the medical image while computer-aided surgery. The main aim of this work was to create an equal-resolution surface registration algorithm (ERSR) and analyze its efficiency.
Methods: The ERSR algorithm provides two datasets with equal, high resolution and approximately corresponding points.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!