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The possible interaction between tryptophan and its metabolites with delirium in older patients with critical illnesses.
Eur Geriatr Med
December 2024
Division of Geriatrics, Department of Internal Medicine, Konya City Hospital, University of Health Sciences Türkiye, Konya, Turkey.
Article Synopsis
- The study explored the link between delirium and tryptophan (TRP) along with its metabolites in older critically ill patients (aged >60) admitted to an ICU, involving 120 participants.* -
- Results showed that patients with delirium had significantly higher levels of kynurenine (KYN)/TRP and quinolinic acid (QA)/TRP ratios and lower TRP levels compared to those without delirium, with the KYN/TRP ratio being a strong predictor for delirium.* -
- The findings suggest that measuring tryptophan and its metabolites within the first 24 hours of ICU admission may help identify patients at high risk for developing delirium.*
A computational signature of self-other mergence in Borderline Personality Disorder.
Transl Psychiatry
November 2024
Max Planck-UCL Centre for Computational Psychiatry and Ageing Research, University College London, London, UK.
A tendency to merge mental representations of self and other is thought to underpin the intense and unstable relationships that feature in Borderline Personality Disorder (BPD). However, clinical theories of BPD do not specify, in computational terms, how the perspectives of self and other might become confused. To address this question, we used a probabilistic false belief task (p-FBT) to examine how individuals with BPD (N = 38) and matched controls from the general population (N = 74) selectively assigned beliefs to self or other.
View Article and Find Full Text PDFValidation of the Three-Factor Reflective Functioning Questionnaire for Youth in a Chinese Adolescent Sample.
Neuropsychiatr Dis Treat
September 2024
Department of Child Psychology, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, National Children's Regional Medical Center, Hangzhou, People's Republic of China.
Purpose: This study focused on the validation of the Three-Factor Reflective Functioning Questionnaire for Youth(RFQY) within a sample of Chinese adolescents.
Patients And Methods: All the items of the RFQY were translated into Chinese language through the process of translation and back translation. A total of 532 adolescents aged between 12-20 years completed the Chinese version of RFQY, McLean Screening Instrument for Borderline Personality Disorder (MSI-BPD), Basic Empathy Scale (BES), and the 20-item Toronto Alexithymia Scale (TAS-20).
Pleomorphic adenoma of hard palate: Review of updated literature and "case report".
Medicine (Baltimore)
September 2024
Department of Oral Medicine and Diagnostic Sciences, College of Dentistry, King Saud University, Riyadh, Saudi Arabia.
Rational: Pleomorphic adenoma (PA) is a rare benign tumor mainly affecting the major salivary glands, known for its diverse histological appearances that can mimic malignancies. When it occurs in the hard palate it present diagnostic and management challenges compared to other sites due to the anatomical location and potential proximity to critical structures. This case reports a rare presentation PA starting as an ulcer, alongside a review of rare cases of PA reported in last 5 years.
View Article and Find Full Text PDFChildhood leprosy in Buenos Aires: four cases report.
Arch Argent Pediatr
December 2024
Dermatology Service; Hospital General de Agudos J. M. Ramos Mejía, City of Buenos Aires, Argentina.
Childhood leprosy, which affects children up to 14 years old, is characterized by a delay in diagnosis since it is usually confused with other dermatoses. Its presence in a child is a relevant epidemiological indicator since it signals active disease transmission. We present 4 patients between 5 and 14 years old who attended a public hospital in Buenos Aires -two patients with borderline tuberculoid leprosy, one with lepromatous leprosy, and one with indeterminate leprosy.
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