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Timing of Complete Multivessel Revascularization in Acute Coronary Syndrome: 2-Year Results of the BIOVASC Study.
JACC Cardiovasc Interv
December 2024
Department of Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, the Netherlands.
Article Synopsis
- In patients with acute coronary syndromes and multivessel disease, immediate and staged complete revascularization showed similar outcomes at 2 years regarding combined health events like mortality and heart attacks.
- A total of 1,525 patients participated, and follow-up data were collected from 97.6% of them.
- The only notable difference was a lower rate of myocardial infarction in the immediate complete revascularization group compared to the staged group, suggesting it might be a slightly better option in preventing heart attacks.
Amino Acid Infusion for Kidney Protection in Cardiac Surgery Patients with Chronic Kidney Disease: A Secondary Analysis of the PROTECTION Trial.
Anesthesiology
December 2024
Department of Critical Care, The University of Melbourne, Melbourne, Australia.
Background: In the PROTECTION trial, intravenous amino acids (AA) decreased the occurrence of acute kidney injury (AKI) in cardiac surgery patients with cardiopulmonary bypass (CPB). Recruitment of renal functional reserve may be responsible for such protection. However, patients with chronic kidney disease (CKD) have diminished renal functional reserve, and AA may be less protective in such patients.
View Article and Find Full Text PDFGlue and Ethanol Mixture for Aneurysm Endovascular Treatment: Animal Lab Study, Imaging, and Histopathological Findings.
J Clin Med
November 2024
"Dipartimento delle Tecnologie Avanzate Diagnostico-Terapeutiche e dei Servizi Sanitari"-UOC Neuroradiologia, Azienda Ospedaliera di Rilievo Nazionale "Antonio Cardarelli", 80131 Napoli, Italy.
This study aims to investigate the degree of penetration, permanence of occlusion, and vascular changes induced by a newly modified mixture of n-butyl cyanoacrylate (Glubran 2), ethanol, and Lipidol (GEL) in the endovascular treatment of experimental aneurysms induced in swine. Bilateral pouch aneurysms were created in the wall of the internal carotid artery in eighteen pigs. The sixteen aneurysms were treated with a new mixture of GEL with different component proportions.
View Article and Find Full Text PDFCold induces increased ad libitum energy intake independent of changes in energy expenditure: a controlled crossover trial in adults.
Am J Clin Nutr
December 2024
Obesity and Diabetes Clinical Research Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, USA.
Background: Measures of energy metabolism [energy expenditure (EE), respiratory exchange ratio (RER)] have been associated with ad libitum energy intake (EI) and weight gain in previous observational studies, suggesting that energy-sensing mechanisms drive EI to meet metabolic energy demands.
Objective: We aimed to employ mild cold exposure as an intervention to alter energy metabolism and evaluate its causal effects on concurrent and next day ad libitum EI.
Methods: In a controlled crossover study, 47 volunteers (16 female; age 37.
Cardiovascular PET imaging of fibroblast activation A review of the current literature.
J Nucl Cardiol
December 2024
BHF Centre of Cardiovascular Science, University of Edinburgh, Edinburgh, United Kingdom.
Fibrosis is one of the key healing responses to injury, especially within the heart where it helps to maintain structural integrity following acute insults such as myocardial infarction. However, if it becomes dysregulated then fibrosis can become maladaptive leading to adverse remodelling, impaired cardiac function and heart failure. Fibroblast activation protein is exclusively expressed by activated fibroblasts, the key effector cells of fibrogenesis, and has a unique extracellular domain that is an ideal ligand for novel molecular imaging probes.
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