Fungal infections are common in tropical countries such as India. Very few clinical cases caused by the Entomophthorales Zygomycetes have been reported. Rhinofacial infection is a rare form of zygomycosis in humans, and only limited information regarding optimal treatment is available. We report here a rare case of rhinofacial Conidiobolus coronatus infection in a previously healthy 18-year-old man who presented with a fungal granuloma of the right inferior turbinate and face. Diagnosis was confirmed by microbiologic culture from a tissue biopsy. The infection was successfully treated with surgery and itraconazole therapy for 12 months. The clinical presentation and treatment of this rare, chronic, indolent form of fungal infection are highlighted in this article.
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Cytokine
January 2025
Museum and Institute of Zoology, Polish Academy of Sciences, Twarda 51/55, 00-818 Warszawa, Poland.
Cytokines are highly conserved between mammals and insects. The present study examines the multiple effects of interferon-gamma (IFN-γ) application on the immunological defence mechanisms of Galleria mellonella larvae, invertebrates which are gaining popularity as a replacement for mammalian research models in immunological studies. G.
View Article and Find Full Text PDFAm J Trop Med Hyg
January 2025
Department of Pathology, Atal Bihari Vajpayee Institute of Medical Sciences and Dr Ram Manohar Lohia Hospital, New Delhi, India.
There are no standard guidelines on the management of Conidiobolus infections, and many antifungals have been used, either alone or in combination. Relapses are common even after successful management. Although localized, they can result in severe facial disfigurement and may rarely cause disseminated entomophthoromycosis, which can have fatal complications.
View Article and Find Full Text PDFJ Invertebr Pathol
September 2024
Museum and Institute of Zoology, Polish Academy of Science, Twarda 51/55, 00-818 Warszawa, Poland; Biomibo, Strzygłowska 15, 04-872 Warsaw, Poland.
This work examines the insecticidal activity of octanoic acid (C8:0), a short-chain fatty acid detected in entomopathogenic fungus - Conidiobolus coronatus medium, against Lucilia sericata larvae and adults. The LD50 value was calculated as 3.04±0.
View Article and Find Full Text PDFFront Immunol
May 2024
Museum and Institute of Zoology, Polish Academy of Science, Warsaw, Poland.
Background: In response to the replace mammal research models with insects in preliminary immunological studies, interest has grown in invertebrate defense systems. The immunological response is regulated by cytokines; however, while their role in mammals is well understood, little is known of their function in insects. A suitable target for studies into insect immunology is (Lepidoptera), the wax moth: a common host for human fungal and bacterial pathogens.
View Article and Find Full Text PDFJ Invertebr Pathol
June 2024
Dipartimento di Scienze Agrarie, Forestali e Alimentari, Università Degli Studi di Torino, Largo Paolo Braccini, 2, 10095 Grugliasco, TO, Italy. Electronic address:
The spittlebug Philaenus spumarius (Hemiptera: Aphrophoridae) is the predominant vector of Xylella fastidiosa (Xanthomonadales: Xanthomonadaceae) in Apulia, Italy and the rest of Europe. Current control strategies of the insect vector rely on mechanical management of nymphal stages and insecticide application against adult populations. Entomopathogenic fungi (EPF) are biological control agents naturally attacking spittlebugs and may effectively reduce population levels of host species.
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