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Deep eutectic solvent-based green extraction of Strychnos potatorum seed phenolics: Process optimization via response surface methodology and artificial neural network.
Talanta
December 2024
Department of Chemistry, Government College University, Lahore, Pakistan. Electronic address:
The current research focused on extraction optimization of bioactive compounds from Strychnos potatorum seeds (SPs) using an eco-friendly glycerol-sodium acetate based deep eutectic solvent (DES). The optimization was accomplished using response surface methodology (RSM) and artificial neural networking (ANN). The independent variables included shaking time (A), temperature (B), and solvent-to-feed ratio (C), and the responses were the extraction yield, total phenolic content (TPC), total flavonoid content (TFC), antioxidant activity (DPPH), and antidiabetic activity (α-amylase inhibitory activity).
View Article and Find Full Text PDFA Cross-Sectional Evaluation of Opioid Dispensing Competencies in Final-Year Pharm-D Students: A Multicenter Study from Punjab, Pakistan.
Drug Healthc Patient Saf
December 2024
Pharmacology and Therapeutics, University Medical & Dental College, the University of Faisalabad, University of Birmingham, Birmingham, UK.
Background: The opioid crisis continues to be a public health concern worldwide due to the high rates of misuse and associated mortality. Opioid dispensing competencies are critical for pharmacy graduates to promote the rational use of opioids.
Purpose: To evaluate the opioids dispensing competencies among the final year Pharm-D students in Punjab, Pakistan.
On brain stimulation in epilepsy.
Brain
January 2025
Department of Neurosurgery, University of Utah, Salt Lake City, UT 84132, USA.
Brain stimulation has, for many decades, been considered as a potential solution for the unmet needs of the many people living with drug-resistant epilepsy. Clinically, there are several different approaches in use, including vagus nerve stimulation (VNS), deep brain stimulation of the thalamus, and responsive neurostimulation (RNS). Across populations of patients, all deliver reductions in seizure load and SUDEP risk, yet do so variably, and the improvements seem incremental rather than transformative.
View Article and Find Full Text PDFEvaluation of Clinical Effect of Acupuncture on Chronic Prostatitis: Meta Analysis.
Am J Mens Health
January 2025
School of Acupuncture-Moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing, China.
This study aims to evaluate the clinical efficacy of acupuncture and moxibustion in CP treatment and assess the quality of clinical literature. Controlled clinical trials (CCT) and randomized controlled trials (RCTs) from PubMed, Web of Science, NLM, CNKI, and Wanfang (January 2003 to January 2023) were analyzed. Relevant data were extracted and statistically analyzed using RevMan 5.
View Article and Find Full Text PDF[Clinical Analysis of High-Dose Melphalan Combined with Autologous Hematopoietic Stem Cell Transplantation for Multiple Myeloma].
Zhongguo Shi Yan Xue Ye Xue Za Zhi
December 2024
Department of Hematology, Yijishan Hospital, Wannan Medical College, Wuhu 241001, Anhui Province, China.
Objective: To investigate the safety, efficacy, and prognosis of high-dose melphalan in combination with autologous hematopoietic stem cell transplantation (ASCT) for the treatment of multiple myeloma (MM).
Methods: The clinical data of 17 patients with newly diagnosed MM who underwent ASCT as first-line consolidation therapy at the Yijishan Hospital of Wannan Medical College from March 2020 to October 2022 were retrospectively analyzed. The safety, efficacy, and prognosis of this treatment approach were evaluated.
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