Failure of ivermectin per rectum to achieve clinically meaningful serum levels in two cases of Strongyloides hyperinfection.

Am J Trop Med Hyg

Division of General Internal Medicine, University Health Network, Toronto, Canada; Division of Infectious Diseases, University Health Network, Toronto, Canada; Department of Medicine, University of Toronto, Toronto, Canada; Division of Infectious Diseases, St. Michael's Hospital, Toronto, Canada; Department of Pharmacy, St. Michael's Hospital, Toronto, Canada; Division of Pharmaceutics and Translational Therapeutics, University of Iowa, Iowa City, Iowa.

Published: July 2015

Two cases of Strongyloides hyperinfection are presented. Ivermectin was initially administered orally and per rectum pending the availability of subcutaneous (SC) preparations. In neither case did rectal suppositories of ivermectin achieve clinically meaningful serum values. Clinicians should use SC preparations of ivermectin as early as possible in Strongyloides hyperinfection and dissemination.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4497912PMC
http://dx.doi.org/10.4269/ajtmh.15-0077DOI Listing

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