AI Article Synopsis
- The study investigates the prognostic value of lymph node density in patients with tongue squamous cell carcinoma (SCC), aiming to see how it affects survival rates.
- The research involved a retrospective analysis of 99 patients who had undergone removal of tongue SCC and neck dissection, focusing on overall survival (OS) and disease-specific survival (DSS).
- Findings indicate that lymph node density serves as a strong independent predictor for OS and DSS, outperforming traditional nodal staging methods and suggesting its potential for better survival predictions in this patient group.
Article Abstract
Background: The prognostic significance of lymph node density in oral squamous cell carcinoma (OSCC) has been well recognized. However, its use in a specific subsite of the tongue has not been evaluated. The purpose of this study was to determine the prognostic significance of lymph node density in tongue squamous cell carcinoma (SCC).
Methods: A retrospective analysis of 99 patients with tongue SCC who underwent primary curative resection and neck dissection was conducted. Overall survival (OS) and disease-specific survival (DSS) was used to evaluate the prognostic significance of lymph node density.
Results: Lymph node density (using a cutoff of 0.06) was shown to be an independent predictor of OS and DSS. The impact of lymph node density on OS and DSS remained significant on multivariate analysis, whereas conventional nodal staging was not. An alternative staging strategy incorporating depth of invasion and lymph node density performs better than conventional TNM staging in predicting survival.
Conclusion: Our data suggest that lymph node density is a reliable and applicable predictor of prognosis in patients with tongue SCC. © 2015 Wiley Periodicals, Inc. Head Neck 38: E859-E866, 2016.
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| http://dx.doi.org/10.1002/hed.24113 | DOI Listing |
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