AI Article Synopsis
- Mast cells can actually support the growth and spread of tumors, and higher numbers of these cells are linked to worse outcomes in cancer patients.
- In various tumor types, the presence of mast cells is associated with increased blood vessel formation, greater tumor aggression, and a higher chance of metastasis.
- Targeting mast cells may offer a new approach for cancer treatment by inhibiting processes that allow tumors to thrive while also boosting immune responses against the cancer.
Article Abstract
Mast cells promote tumorigenesis and tumor progression, and have functions that favor the host. Increased mast cell number correlates with a poor prognosis in several human tumors. In different vascular tumors, as well as a number of hematological and solid tumors, mast cell accumulation correlate with increased neovascularization, tumor aggressiveness, and metastatic spread. Mast cells might act as a new target for the adjuvant treatment of tumors through the selective inhibition of angiogenesis, tissue remodeling and tumor-promoting molecules, permitting the secretion of cytotoxic cytokines and preventing mast cell-mediated immune suppression.
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| http://dx.doi.org/10.1016/j.ejphar.2015.02.056 | DOI Listing |
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