An efficient approach to 3-alkynylpyrroles has been developed through the gold-catalyzed reaction of β-enamino derivatives with terminal alkynes, which features complete regiocontrol, relatively wide substrate scope, and high functional group tolerance. Mechanistic studies show that the reaction proceeds through the gold-catalyzed cascade oxidative C-H/C-H cross-coupling, cyclization and alkynylation.
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| http://dx.doi.org/10.1039/c5ob00599j | DOI Listing |
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