AI Article Synopsis
- Existing biosensors consist of two key parts: analyte recognition for specificity and signal transduction, which often involves a complicated chemical amplification stage to boost sensitivity.
- This chemical amplification can make the sensing process more complex and slow down the response time, as it separates the two main components.
- The review highlights new mechanochemical biosensors that use mechanochemical coupling to directly monitor mechanical changes at the single-molecule level, allowing for high sensitivity without the need for additional amplification, thus enabling real-time sensing.
Article Abstract
Existing biosensors employ two major components: analyte recognition and signal transduction. Although specificity is achieved through analyte recognition, sensitivity is usually enhanced through a chemical amplification stage that couples the two main units in a sensor. Although highly sensitive, the extra chemical amplification stage complicates the sensing protocol. In addition, it separates the two elements spatiotemporally, reducing the real-time response of the biosensor. In this review, we discuss the new mechanochemical biosensors that employ mechanochemical coupling strategies to overcome these issues. By monitoring changes in the mechanical properties of a single-molecule template upon analyte binding, single-molecule sensitivity is reached. As chemical amplification becomes unnecessary in this single-molecule mechanochemical sensing (SMMS) strategy, real-time sensing is achieved.
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| http://dx.doi.org/10.1002/cphc.201500080 | DOI Listing |
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