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http://dx.doi.org/10.3389/fncel.2015.00133 | DOI Listing |
J Neurosurg Spine
January 2025
7Department of Orthopaedics, University of British Columbia, Vancouver, British Columbia, Canada; and.
FEBS Open Bio
January 2025
FEBS Open Bio Editorial Office, Cambridge, UK.
Different societal, systemic and personal barriers exist at various stages along a female researcher's career that can potentially undermine their success. The equation for women to reach higher positions in STEM is a multivariable one, and while there has been considerable progress towards addressing some of these compared with the past, current solutions are inadequate and do not address all facets. Here, we asked female winners of the FEBS Open Bio poster prize about their experiences regarding barriers they have faced at the predoctoral and postdoctoral stages, their opinions on how these can be addressed and their advice to new students entering a PhD degree.
View Article and Find Full Text PDFJ Med Chem
January 2025
Experimental Drug Development Centre, Chromos, Agency for Science, Technology and Research, 10 Biopolis Road, #05-01, Singapore 138670.
The discovery of molecular glues has made significant strides, unlocking new avenues for targeted protein degradation as a therapeutic strategy, thereby expanding the scope of drug discovery into territories previously considered undruggable. Pioneering molecules like thalidomide and its derivatives have paved the way for the development of small molecules that can induce specific protein degradation by hijacking the cellular ubiquitin-proteasome system. Recent advancements have focused on expanding the range of E3 ligases and target proteins that can be modulated by molecular glues.
View Article and Find Full Text PDFJ Eur Acad Dermatol Venereol
February 2025
Department of Allergy, Dermatology and Venereology, Herlev & Gentofte University Hospital, Gentofte, Denmark.
Genesis
December 2024
University at Albany, State University of New York, New York City, New York, USA.
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