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Eye reactions under the influence of drugs of abuse as measured by smartphones: a controlled clinical study in healthy volunteers.
Front Neurosci
January 2025
Kontigo Care AB, Uppsala, Sweden.
Background: It is known that illicit and prescribed drugs impact pupil size, eye movement and function. Still, comprehensive quantitative evaluations under known ambient light conditions are lacking, when smartphones are used for monitoring.
Methods: In this clinical study (NCT05731999), four medicinal products with addiction risks were administered to 48 subjects (18-70 years old, all with informed consent, 12 subjects per drug).
Co-isolation of human donor eye cells and development of oncogene-mutated melanocytes to study uveal melanoma.
BMC Biol
January 2025
Cancer Research Program, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Background: Uveal melanoma (UM) is the most common intraocular tumor in adults, arises either de novo from normal choroidal melanocytes (NCMs) or from pre-existing nevi that stem from NCMs and are thought to harbor UM-initiating mutations, most commonly in GNAQ or GNA11. However, there are no commercially available NCM cell lines, nor is there a detailed protocol for developing an oncogene-mutated CM line (MutCM) to study UM development. This study aimed to establish and characterize premalignant CM models from human donor eyes to recapitulate the cell populations at the origin of UM.
View Article and Find Full Text PDFChanges in tear cytokine and lactoferrin levels in postmenopausal women with primary acquired nasolacrimal duct obstruction complicated with obstructed meibomian gland dysfunction.
BMC Ophthalmol
January 2025
Department of Ophthalmology, Wuhu Eye Hospital, 378 Santan Road, Yijiang District, Anhui Province, Wuhu, 241002, China.
Background: Epiphora and secondary ocular surface damage are increasingly impairing the quality of life of people, particularly elderly women. We aimed to investigate the changes in tear cytokine and lactoferrin levels in postmenopausal women with primary acquired nasolacrimal duct obstruction (PANDO) complicated with obstructed meibomian gland dysfunction (OMGD) and preliminary explore the pathological mechanisms of OMGD in patients with PANDO.
Methods: The prospective study involved 43 and 41 postmenopausal women with and without PANDO, respectively.
Comparison of different decellularization methods for human anterior lens capsules.
BMC Ophthalmol
January 2025
Eye Institute, Affiliated Hospital of Nantong University, Nantong, Jiangsu Province, China.
Background: Human anterior lens capsules (ALCs) have great potential in the treatment of multiple eye diseases, including corneal ulcers, glaucoma, age-related macular degeneration and macular holes. ALCs are also regarded as promising scaffolds for various ocular cells. Here, we investigated different decellularization methods for removing lens epithelial cells (LECs) that adhered to ALCs.
View Article and Find Full Text PDFMycoplasma Pneumonia Complicated by Stevens-Johnson Syndrome: A case report.
Respir Med Case Rep
July 2024
Faculty of Medicine, Beirut Arab University, Beirut, Lebanon.
Mycoplasma pneumoniae is a leading cause of a community-acquired respiratory illness occurring in children with manifestations occurring throughout the year but peaking in summer and early fall. Predominantly affecting school-aged children, the infection presents as pneumonia, featuring fever, cough, dyspnea, and sore throat. Extrapulmonary manifestations such as Stevens-Johnson have been rarely associated with mycoplasma pneumoniae infection presenting with ocular, oral, and genital involvement.
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