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T Cells Induce Prolonged Downregulation of Barrier Molecules in a Mouse Model of Allergic Contact Dermatitis.
Allergy
December 2024
The LEO Foundation Skin Immunology Research Center, Department of Immunology and Microbiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Background: Dysfunction of the skin barrier is regarded as a key event in the initiation and progression of inflammatory skin diseases. In many cases of allergic contact dermatitis (ACD), epidermal-resident memory CD8 T (T) cells play a central role in the immune response to contact allergens. However, if and how allergen-specific CD8 T cells affect the expression of skin barrier molecules is not known.
View Article and Find Full Text PDFPredicting allergen immunotherapy efficacy based on early maintenance phase response in routine clinical practice.
World Allergy Organ J
December 2024
State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Department of Allergy and Clinical Immunology, The First Affiliated Hospital of Guangzhou Medical University, 151, Yanjiangxi Rd, Guangzhou, Guangdong, 510120, China.
Background: While allergen-specific immunotherapy (AIT) is acknowledged as an effective treatment, its efficacy varies, and consensus on predictive indicators for AIT responders remains elusive.
Objective: This study aimed to identify alternative parameters for predicting AIT responders based on clinical data collected in daily practice.
Method: We conducted a retrospective analysis of patients with house-dust-mite-driven asthma and/or rhinitis who completed 3 years of subcutaneous AIT (3y-AIT).
Combined Dupilumab and Allergen-Specific Immunotherapy in Severe Refractory Atopic Dermatitis.
Allergy Asthma Immunol Res
November 2024
Department of Dermatology and Cutaneous Biology Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
Article Synopsis
- Combining allergen immunotherapy with biologics like dupilumab shows potential in treating severe atopic dermatitis (AD), which hasn't been extensively researched compared to conditions like asthma and allergic rhinitis.
- A study conducted at Severance Hospital in Korea evaluated the efficacy and safety of this combination therapy in 48 patients with severe AD, assessing treatment outcomes over 144 weeks based on established clinical scores and biomarker levels.
- Results indicated significant improvements in AD severity, decreased IgE levels, increased allergen-specific IgG4, and only mild side effects, suggesting this combined approach could be a beneficial option for patients who don't respond to standard treatments.
Construction of a Hybrid Vaccine Based on Der f 35-Derived Peptides with Reduced Allergenicity.
Int Arch Allergy Immunol
November 2024
Department of Clinical Laboratory, The Second Affiliated Hospital of Nantong University, Nantong, China.
Introduction: House dust mite is the primary trigger of allergic respiratory diseases worldwide, and allergen-specific immunotherapy (AIT) is the only disease-modifying treatment in the clinic. The use of allergen molecules instead of extracts is a promising strategy in AIT. In this study, we constructed a peptide hybrid vaccine against the major mite allergen Der f 35 and verified its hypoallergenicity, making it to be a promising candidate for AIT of mite allergy.
View Article and Find Full Text PDFDevelopment of Cashew and Pistachio Ladders through a Food-Processing Approach.
Foods
October 2024
School of Chemical Engineering, University of New South Wales, Kensington, NSW 2052, Australia.
Following successful oral immunotherapy (OIT) for peanut allergy using boiled peanuts (BOPI trial), this study investigated the potential of wet-thermal-processing-induced allergen modification, specifically soaking and boiling (1-4 h) to reduce the allergenicity of cashew and pistachio allergens. In addition, this study provides a foundation of understanding for developing safer forms of cashew/pistachio administration for application in OIT by gradual exposure to increasing doses of modified allergens with reduced potency as an "allergen ladder". An SDS-PAGE analysis and an intrinsic-fluorescence spectroscopy revealed altered tertiary structures of the allergens, leading to their denaturation and even degradation.
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