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Melorheostosis of the cervical and cervicothoracic spine: review of the literature and presentation of 3 new cases.
Arch Orthop Trauma Surg
August 2024
Spine Surgery, Orthopedics, Traumatology, SRH Klinikum Karlsbad, Guttmannstrasse 1, 76307, Karlsbad - Langensteinbach, Germany.
Melorheostosis is a rare dysplastic bone disease that usually affects long bones at the upper or lower limbs. It is rarely seen at the spine and very rarely located at the cervical spine. To the best of our knowledge, there are currently 6 cases of melorheostosis described at the cervical spine.
View Article and Find Full Text PDFSpinal Melorheostosis: A Rare Presentation.
JBJS Case Connect
July 2023
Department of Pathology, Istanbul Medipol University Faculty of Medicine, Istanbul, Turkey.
Case: A 22-year-old female patient was referred to the orthopaedic department for further examination after a radiopaque area was observed in the T6 vertebra in her chest radiograph. Computed Tomography (CT) showed a sclerotic mass with smooth borders, involving the entire body of the T6 vertebra, left posterior elements, posterior of the rib past the left zygapophyseal joint, and a "flowing candle wax" image toward the T7 vertebra. Spinal melorheostosis was considered radiologically in the patient, but malignancy could not be completely excluded.
View Article and Find Full Text PDFThe periosteal "dripping candle wax" sign: Classic melorheostosis.
Joint Bone Spine
December 2023
Diagnostic and Interventional Radiology, IRCCS Istituto Ortopedico Rizzoli, Via G.C. Pupilli 1, 40136 Bologna, Italy.
Spinal Melorheostosis Associated with Intradural Fibrous Band and Extensive Lipomatosis Causing Thoracic Cord Tethering and Myelomalacia: A Unique Case Highlighting Importance of MRI in Management.
Indian J Radiol Imaging
September 2022
Department of Orthopaedics and Spine Surgery, Ganga Hospital, Coimbatore, Tamil Nadu, India.
Axial melorheostosis is rare with only few cases reported and even fewer with symptoms. While symptoms secondary to neural foramen or spinal canal stenosis caused by hyperostotic bone are common, only three symptomatic cases of spinal melorheostosis with associated intradural lipomatous lesions have been reported to date. In none of them the fibrous component of lipofibromatous lesion was identified preoperatively on magnetic resonance imaging.
View Article and Find Full Text PDFClinical characteristics of 10 Chinese patients with melorheostosis and identification of a somatic MAP2K1 variant in one case.
Mol Genet Genomic Med
October 2022
Shanghai Clinical Research Center of Bone Disease, Department of Osteoporosis and Bone Disease, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China.
Background: Melorheostosis (MEL) is an exceptionally rare sclerosing bone dysplasia with asymmetrically exuberant bone formation and soft tissue lesions in a segmental distribution. We aimed to summarize the clinical characteristics of Chinese MEL patients and identify their pathogenic cause.
Methods: In total, 10 Chinese MEL patients were recruited, and clinical manifestations and radiological characteristics were recorded.
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