AI Article Synopsis
- Juvenile nasopharyngeal angiofibroma (JNA) is a rare and benign tumor primarily affecting adolescent males, but its causes and growth patterns are not well understood.
- Researchers studied Toll-like receptors (TLRs) in 27 JNA specimens to explore their role in tumor development.
- The findings indicated that TLR 3, 7, and 9 were present and varied in expression in JNA tissues, and TLR 3 levels specifically correlated with the tumor's clinical stage, suggesting TLRs may influence JNA growth.
Article Abstract
Unlabelled: Juvenile nasopharyngeal angiofibroma (JNA) is a rare, benign tumor affecting adolescent males. The etiology of JNA as well as the causes determining the variable growth patterns of individual tumors remains unknown. Toll-like receptors (TLRs) are part of the innate immune response to microbes; by recognition of distinct features, they link to induction of pro-inflammatory signaling pathways. We immunostained TLR 3, 7, and 9 in 27 JNA specimens of patients treated at the Helsinki University Central Hospital, Helsinki, Finland, during the years 1970-2009.
Results: TLR 3, 7, and 9 expressions were found in stromal and endothelial cells of JNA, and their expression levels varied from negative to very strong positive. TLR 3 expression was found to have a significant correlation with the clinical stage of JNA.
Conclusions: The present results propose a putative role of TLRs in the growth process of JNA.
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| http://dx.doi.org/10.1111/apm.12366 | DOI Listing |
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