AI Article Synopsis
- Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) show clinical diversity, but there is limited data on Chinese patients, prompting a study analyzing 294 cases from 2007 to 2012.
- The most common tumor site was the rectum, with abdominal pain being the primary symptom; the study found varying grades of tumors (G1-G3) and emphasized that endoscopy was the most effective detection method.
- Results indicated that factors like tumor size, location, grade, and presence of metastasis negatively impacted patient outcomes, with a 5-year survival rate of 69.6%, while some findings were consistent with previous studies, others showcased notable differences.
Article Abstract
Background/aims: Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) are a unique subgroup of tumors in the digestive system but with great clinical heterogeneity. The information on clinical characteristics and prognostic factors of Chinese patients is rather limited.
Methodology: We retrospectively analyzed the clinical features, prognostic factors of this disease in a consecutive cohort (N=294) between January 2007 and December 2012.
Results: Functioning tumors accounted for 9.2%. Rectum was the most predominant GEP-NETs locations. Abdominal pain occurred in 46.5% patients which was the most common initial symptom. G1, G2 and G3 tumors accounted for 41.5%, 34.7% and 23.8%, respectively. Endoscopy provided the highest detection rate of 95.7%. Consistence between endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNAB) and surgically obtained histological Ki-67 index was 36.4%. Serum CgA test showed a 80.0% consistence with the tissue biopsy. The median follow up duration was 2.8 years (0.02-5.90 years), the median survival was 4.8 years, overall 5-year survival rate was 69.6%. We found colonic localization, tumor size larger than 20 mm, G3 tumor and metastasis were associated with worse outcome (p<0.05).
Conclusion: We found both consistence and differences in GEP-NETs characteristics between our study and previous reports.
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