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This study aims to mine and analyze adverse events (AEs) of Vedolizumab based on the FAERS database to better understand its safety and potential risks in the real world. Data from the second quarter of 2014 to the third quarter of 2023 were collected, employing various signal mining methods such as Reporting Odds Ratio (ROR), Proportional Reporting Ratio (PRR), Bayesian Confidence Propagation Neural Network (BCPNN), and Empirical Bayesian Geometric Mean (EBGM). The study gathered 14,753,012 reports of AEs, of which 46,726 were related to Vedolizumab.
View Article and Find Full Text PDFCloth versus disposable diapers: an exploratory study on family habits.
J Pediatr (Rio J)
December 2024
Universidade Federal do Paraná (UFPR), Departamento de Pediatria, Divisão de Dermatologia Pediátrica, Curitiba, Brazil.
Objective: To describe features and habits of diaper area care and compare the frequency of diaper dermatitis in infants using cloth diapers with those using disposable diapers.
Methods: Questionnaires were administered to families with infants who had not started potty training, to assess the frequency of diaper rash in two groups: babies who use exclusively cloth diapers (CD), and others with exclusively disposable diapers (DD). The hygiene methods of the perineal region and the skin lesions frequency were evaluated.
[Clinicopathological study of 24 cases of monkeypox virus infection-related rashes].
Zhonghua Bing Li Xue Za Zhi
October 2024
Department of Pathology, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China.
Article Synopsis
- The study investigates the clinicopathological characteristics of rashes in monkeypox patients through skin biopsies at Beijing Ditan Hospital, focusing on 24 male patients, some with HIV.
- Findings show that monkeypox rashes are primarily solitary, distributed across areas like the perineum and face, with key pathological features including ballooning degeneration and Guarnieri's bodies.
- The research highlights effective diagnostic methods such as histopathology and electron microscopy, revealing the monkeypox virus's ability to infect various skin cell types, suggesting its unique affinity for epithelial tissues.
Analysis of similarities and differences between transient symptomatic zinc deficiency and acrodermatitis enteropathica in children: a case report of a Chinese Yi-ethnic infant.
BMC Pediatr
May 2024
Department of Pediatrics, Yibin Hospital Affiliated to Children's Hospital of Chongqing Medical University, No. 108, Shangmao road, Xuzhou district, Yibin, Sichuan, P.R. China.
Article Synopsis
- Transient symptomatic zinc deficiency (TSZD) is a rare but often overlooked condition primarily affecting breastfed premature infants, showing symptoms that closely resemble those of Acrodermatitis enteropathica (AE), a genetic disorder caused by mutations in the SLC39A4 gene.* -
- A case study of a 4-month-old infant diagnosed with TSZD revealed significantly low blood zinc levels, while genetic testing confirmed no mutations in the SLC39A4 gene, differentiating it from AE.* -
- The infant showed significant improvement following zinc supplementation, highlighting the importance of genetic analysis in accurately diagnosing TSZD versus AE to avoid misdiagnosis.*
Case 15-2024: A 73-Year-Old Woman with Worsening Rash.
N Engl J Med
May 2024
From the Departments of Medicine (S.T.C., S.J.), Dermatology (S.T.C.), Radiology (R.L.C.), Pathology (A.M.S.), and Ophthalmology (A.M.S), Massachusetts General Hospital, the Departments of Medicine (S.T.C., S.J.), Dermatology (S.T.C.), Radiology (R.L.C.), Pathology (A.M.S.), and Ophthalmology (A.M.S), Harvard Medical School, and the Department of Ophthalmology, Mass Eye and Ear (A.M.S.) - all in Boston.
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