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Different MHC class I cell surface expression levels in diverse chicken lines, associations with B blood group, and proposed relationship to antigen-binding repertoire.
Poult Sci
November 2024
Department of Animal Science, Iowa State University, 806 Stange Road, 2255 Kildee Hall, Ames, IA 50011, USA. Electronic address:
The Major Histocompatibility Complex (MHC) is a cluster of genes with primarily immune-related functions. The MHC class I genes are responsible for self- versus non-self-recognition and viral antigen presentation to T lymphocytes. The chicken MHC class I protein binds its cognate antigen(s) over a repertoire spectrum ranging from promiscuous (generalist) to fastidious (specialist).
View Article and Find Full Text PDFExploring red blood cells as an antigen delivery system to modulate the immune response towards FVIII in hemophilia A.
J Thromb Haemost
November 2024
Department of Molecular Hematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands. Electronic address:
Background: The main complication in hemophilia A treatment is the development of inhibitory antibodies against factor (F)VIII. Immune tolerance induction, the gold standard for eradicating anti-FVIII antibodies, is efficient in only 60% to 80% of cases. This underscores the need for more efficient induction of tolerance in patients with hemophilia A with FVIII inhibitors.
View Article and Find Full Text PDFDesign of a multi-epitope vaccine candidate against carrion disease by immunoinformatics approach.
Comput Biol Med
January 2025
Molecular Microbiology and Biotechnology Laboratory, Faculty of Biological Sciences, Universidad Nacional Mayor de San Marcos, Lima, Peru. Electronic address:
Carrion's disease, caused by the bacterium Bartonella bacilliformis, is a serious public health problem in Peru, Ecuador and Colombia. Currently there is no available vaccine against B. bacilliformis.
View Article and Find Full Text PDFAntigen presentation for central tolerance induction.
Nat Rev Immunol
January 2025
Institute for Immunology, Biomedical Center (BMC), Faculty of Medicine, LMU Munich, Planegg-Martinsried, Germany.
The extent of central T cell tolerance is determined by the diversity of self-antigens that developing thymocytes 'see' on thymic antigen-presenting cells (APCs). Here, focusing on insights from the past decade, we review the functional adaptations of medullary thymic epithelial cells, thymic dendritic cells and thymic B cells for the purpose of tolerance induction. Their distinct cellular characteristics range from unconventional phenomena, such as promiscuous gene expression or mimicry of peripheral cell types, to strategic positioning in distinct microenvironments and divergent propensities to preferentially access endogenous or exogenous antigen pools.
View Article and Find Full Text PDFPrediction of promiscuous multiepitope-based peptide vaccine against RdRp of rotavirus using immunoinformatics studies.
Rev Inst Med Trop Sao Paulo
September 2024
Qassim University, College of Medicine, Department of Pathology, Buraidah, Saudi Arabia.
Article Synopsis
- Rotavirus, a segmented dsRNA virus, has its VP1 gene encoding RNA-dependent RNA polymerase (RdRp), which is targeted for a potential multiepitope vaccine using immunoinformatic methods.
- The study analyzed 100 nucleotide sequences from various global strains to create a consensus sequence, identifying 27 highly immunogenic and promising T-cell and B-cell epitopes for the vaccine.
- Results show strong binding interactions and immunogenic responses for the multiepitope vaccine, indicating its potential effectiveness in reducing rotavirus infections globally.
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