The removal of two blood lipid regulators, clofibric acid (CLA) and gemfibrozil (GFZ), was evaluated using two identical aerobic membrane bioreactors with 6.5 L effective volume each. Polysulfone ultrafiltration hollow fiber membranes were submerged in the reactors. Different operating conditions were tested varying the organic load (F/M), hydraulic residence time (HRT), biomass concentration measured as total suspended solids in the mixed liquor (MLTSS) and the sludge retention time (SRT). Complete GFZ removal was obtained with F/M of 0.21-0.48 kg COD kgTSS⁻¹ d⁻¹, HRT of 4-10 hours, SRT of 10-32 d and MLTSS of 6-10 g L⁻¹. The GFZ removal can be attributed to biodegradation and there was no accumulation of the compound in the biomass. The CLA removals improved with the SRT and HRT increase and F/M decrease. Average removals of 78-79% were obtained with SRT 16-32 d, F/M of 0.21-0.34 kgCOD kgTSS⁻¹ d⁻¹, HRT of 7-10 hours and MLTSS of 6-10 g L⁻¹. Biodegradation was found to be the main removal pathway.
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http://dx.doi.org/10.2166/wst.2015.079 | DOI Listing |
Environ Technol
November 2024
School of Civil & Environmental Engineering and Geography Science, Ningbo University, Ningbo, People's Republic of China.
Front Chem
July 2024
Department of Pharmacy, University of Naples, Naples, Italy.
BAR502, a bile acid analogue, is active as dual FXR/GPBAR1 agonist and represents a promising lead for the treatment of cholestasis and NASH. In this paper we report the synthesis and the biological evaluation of a library of hybrid compounds prepared by combining, through high-yield condensation reaction, some fibrates with BAR502.The activity of the new conjugates was evaluated towards FXR, GPBAR1 and PPARα receptors, employing transactivation or cofactor recruitment assays.
View Article and Find Full Text PDFBiomed Pharmacother
July 2024
Centre for Host-Microbiome Interactions, Faculty of Dentistry, Oral & Craniofacial Sciences, King's College London, London SE1 9RT, UK; Science for Life Laboratory, KTH-Royal Institute of Technology, Stockholm SE-17165, Sweden. Electronic address:
Sarcopenia is a major public health concern among older adults, leading to disabilities, falls, fractures, and mortality. This study aimed to elucidate the pathophysiological mechanisms of sarcopenia and identify potential therapeutic targets using systems biology approaches. RNA-seq data from muscle biopsies of 24 sarcopenic and 29 healthy individuals from a previous cohort were analysed.
View Article and Find Full Text PDFChemosphere
July 2024
Department of Civil and Environmental Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea. Electronic address:
Although a series of past studies proved the potential usage of Fe-based metal-organic frameworks (MOFs) as photocatalysts, there remains a knowledge gap of the photocatalytic mechanism stemming from the challenge to separate the simultaneous sorption and photocatalytic degradation. Thus, this article aimed to suggest a novel approach by desorbing target molecules during photocatalysis to excavate the underlying mechanisms of sorption and photocatalytic degradation. In this study, two Fe-based MOFs, MIL-101(Fe) and MIL-101(Fe)-NH, were selected to remove clofibric acid under visible light irradiation.
View Article and Find Full Text PDFAppl Microbiol Biotechnol
April 2024
Microbiology, Department of Biology, Utrecht University, Padualaan 8, Utrecht, 3584 CH, the Netherlands.
Water bodies are increasingly contaminated with a diversity of organic micropollutants (OMPs). This impacts the quality of ecosystems due to their recalcitrant nature. In this study, we assessed the removal of OMPs by spent mushroom substrate (SMS) of the white button mushroom (Agaricus bisporus) and by its aqueous tea extract.
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