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Unveiling sialoglycans' immune mastery in pregnancy and their intersection with tumor biology.
Front Immunol
December 2024
Medical Genetic Institute of Henan Province, Henan Key Laboratory of Genetic Diseases and Functional Genomics, National Health Commission Key Laboratory of Birth Defects Prevention, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, Zhengzhou University, Zhengzhou, Henan, China.
Sialylation is a typical final step of glycosylation, which is a prevalent post-translational modification of proteins. Sialoglycans, the products of sialylation, are located on the outmost of cells and participate in pivotal biological processes. They have been identified as glyco-immune checkpoints and are currently under rigorous investigation in the field of tumor research.
View Article and Find Full Text PDFIntracranial hemorrhage and additional anomalies detected on prenatal magnetic resonance imaging: A large, retrospective study in two tertiary medical institutions.
Heliyon
December 2024
Department of Radiology, Obstetrics and Gynecology Hospital, Fudan University, PR China.
Objectives: To clarify the prenatal magnetic resonance (MR) imaging characteristics of fetal intracranial haemorrhages (ICHs) in a large cohort and correlate them with birth outcomes.
Methods: We retrospectively reviewed MR images of fetuses with ICH on screening ultrasound (US) on picture archiving communication system (PACS) servers within a nearly ten-year period from two medical tertiary centres. The indications, main abnormal findings and coexistent anomalies were recorded by two experienced radiologists with census readings.
Fetal Ascites: Its Prenatal Management and Postnatal Outcome.
J Obstet Gynaecol India
December 2024
Department of Fetal Medicine, Amrita Institute of Medical Sciences, Ponekkara, Kochi, Kerala 682041 India.
Objective: To report a single tertiary center experience in the management of prenatally diagnosed cases of fetal ascites and their postnatal outcomes.
Methods: Prenatally diagnosed fetal ascites cases were retrospectively analyzed from 2015 to 2022 using two-dimensional ultrasound with other investigations as required in a tertiary care center.
Results: Of 126 fetuses with fetal ascites, 70 progressed to hydrops and hence were excluded from the study.
Effect of maternal beta-blocker treatment on mean fetal heart rate.
AJOG Glob Rep
February 2025
Assistance Publique-Hôpitaux de Paris, Service de Gynécologie-Obstétrique, Hôpital Bicêtre, Université Paris Saclay, Le Kremlin-Bicetre, France (Hautier and Luton).
Background: During pregnancy, the prescription of beta-blockers to the mother may be necessary for pre-existing chronic conditions. Their use raises concerns due to potential effects on the fetus.
Objectives: This study aimed to investigate the impact of beta-blockers on mean fetal heart rate in pregnant women treated with these medications compared to an untreated patient group.
Umbilical vein remodeling is associated with pregestational maternal overweight.
Front Endocrinol (Lausanne)
December 2024
Institute of Health and Biological Science, Federal University of Mato Grosso, Barra do Garças, Brazil.
Introduction: Excess weight during pregnancy is a condition that can affect both mother and fetus, through the maternal-fetal interface, which is constituted by the placenta and umbilical cord. The umbilical vein is responsible for transporting oxygen and nutrients to the fetus, and its proper functioning depends on the integrity of its structure. The remodeling of the umbilical vein represents one of the causes of inadequate transport of nutrients to the fetus, being potentially harmful.
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