AI Article Synopsis
- A technique called polarization-sensitive optical coherence tomography (OCT) is used for quantitative image analysis to diagnose bladder mucosal pathologies in live patients.
- The Integral Depolarization Factor (IDF) is a new image metric introduced to facilitate automatic diagnosis and assess the health of collagen fibers in the bladder.
- The IDF shows high diagnostic accuracy rates: 79% for severe fibrosis, 97% for detecting carcinoma recurrence, and 75% for distinguishing between neoplasia and acute inflammation, showing strong potential for use in human urology.
Article Abstract
Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is thus demonstrated in vivo.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4399683 | PMC |
| http://dx.doi.org/10.1364/BOE.6.001464 | DOI Listing |
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