AI Article Synopsis
- A new protocol is introduced for creating enantiomerically pure bicyclo[3.3.0]octane derivatives from a specific achiral precursor.
- The technique utilizes a selective deprotection method to achieve diastereomeric resolution.
- This process generates chiral building blocks that maintain a consistent carbonyl functional group within the bicyclo[3.3.0]octane structure.
Article Abstract
A protocol is presented for an efficient and practical approach to the synthesis of enantiomerically pure bicyclo[3.3.0]octane derivatives from achiral Cs-symmetric bicyclo[3.3.0]octane-2,8-dione using a diastereomeric resolution-selective deprotection method. This method affords chiral building blocks having bicyclo[3.3.0]octane framework with the same site of diastereotopic carbonyl functional group.
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| http://dx.doi.org/10.1002/chir.22450 | DOI Listing |
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