AI Article Synopsis
- Pancreatic ductal adenocarcinoma is an aggressive cancer with poor prognosis, highlighting the need for new diagnostic and prognostic biomarkers.
- This study analyzed microRNA expression in 74 tumor tissues, 18 chronic pancreatitis tissues, and 9 normal tissues, finding significant differences in levels of certain microRNAs.
- The results suggest that specific microRNAs may serve as potential biomarkers for diagnosis and prognosis, as their levels correlate with disease progression and patient survival outcomes.
Article Abstract
Background: Pancreatic ductal adenocarcinoma is an aggressive malignancy with late presentation, metastatic potential and very poor prognosis. Therefore, there is an urgent need for novel diagnostic and prognostic biomarkers. MicroRNAs are small non-coding RNAs that post-transcriptionally regulate gene expression. Altered expression of microRNAs has been reported in wide range of malignancies, including pancreatic ductal adenocarcinoma. The aim of this study was to analyze the expression of selected microRNAs in normal pancreas, chronic pancreatitis and pancreatic ductal adenocarcinoma tissues and evaluate their diagnostic and prognostic potential.
Findings: Using quantitative real-time PCR, expression levels of 4 microRNAs were examined in 74 tumor tissues, 18 tissues of chronic pancreatitis and 9 adjacent normal tissues and correlated with clinicopathological features of patients. Expression levels of miR-21, miR-34a and miR-198 were significantly higher, whereas levels of miR-217 were significantly lower in pancreatic ductal adenocarcinomas compared to healthy tissues and tissues of chronic pancreatitis. Moreover, increased expression of miR-21 and miR-198 was significantly associated with shorter disease free survival and overall survival.
Conclusions: Our data suggest that altered expression of examined microRNAs is related to neoplastic transformation and progression of the disease and these microRNAs could serve as diagnostic and prognostic biomarkers for pancreatic ductal adenocarcinoma.
Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1373952531543898.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4407796 | PMC |
| http://dx.doi.org/10.1186/s13000-015-0272-6 | DOI Listing |
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