AI Article Synopsis
- The study aimed to determine how common the PLA2R1 antigen is in kidney biopsy samples from patients with idiopathic membranous nephropathy (IMN) and to understand its connection to the disease.
- Out of 108 patients, 41 were diagnosed with IMN, and an immunofluorescence assay revealed that 85.37% of those with IMN tested positive for the PLA2R1 antigen, while it was absent in other types of kidney diseases.
- Despite the high prevalence of PLA2R1 in IMN patients, the research found no significant differences in clinical measures like age or protein levels between those who were positive and negative for the antigen.
Article Abstract
Objective: To investigate the prevalence of PLA2R1 in renal biopsy specimens of patients with idiopathic membranous nephropathy (IMN) and explore the relationship between PLA2R1 and IMN.
Methods: A total of 108 adult patients with biopsy-proved glomerular diseases were enrolled in this study, including 41 with IMN, 2 with hepatitis B-associated membranous nephropathy, 8 with V lupus nephritis, 27 with IgA nephropathy, 19 with minimal change nephropathy, 5 with mild mesangial proliferative glomerulonephritis, and 6 with focal segmental glomeruloselerosis (FSGS). Indirect immunofluorescence assay was used to detect PLA2R1 in the biopsy specimens and the clinical variables of the IMN patients were analyzed.
Results: In 35 of the 41 (85.37%) patients with IMN, PLA2R1 was detected with a fine granular pattern in the subepithelial deposits along the glomerular capillary loops. PLA2R1 antigen was not detected in patients with other glomerulopathies. No significant differences were found in age, serum creatinine, serum albumin, or 24-h urinary protein level between PLA2R1-positive and negative patients with IMN (P>0.05).
Conclusion: According to our results, 85.37% of adult patients with biopsy-proven IMN are positive for PLA2R1 antigen, which, however, does not contribute to variations of the patients' clinical manifestations.
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