Importance: To describe a cohort of patients with birdshot chorioretinopathy who did not manifest birdshot lesions on clinical examination but had retinal vasculitis, low-grade to moderate vitritis, and hypocyanescent lesions on indocyanine green angiography (ICGA).
Observations: Case series of 3 patients with mild to moderate vitritis and retinal vasculitis without definite birdshot lesions on clinical examination evaluated from January 2007 to December 2014 at 4 academic ophthalmology centers. All patients' results were positive for human leukocyte antigen-A29. All cases had hypocyanescent lesions visible on ICGA but not detectable on fluorescein angiography.
Conclusions And Relevance: Patients with retinal vasculitis and low-grade vitritis with or without macular edema may have birdshot chorioretinopathy evident on ICGA before lesions are visible on clinical examination or fluorescein angiography. Expanding birdshot chorioretinopathy diagnostic criteria to include the presence of hypocyanescent lesions on ICGA could improve the sensitivity of diagnosis.
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http://dx.doi.org/10.1001/jamaophthalmol.2015.0822 | DOI Listing |
Oman J Ophthalmol
October 2024
Department of Uvea, Sankara Nethralaya, Chennai, Tamil Nadu, India.
The white dot syndromes are a group of phenotypically similar disorders characterized by multiple lesions at the level of the outer retina, retinal pigment epithelium, and choroid. Common white dot syndromes whose imaging modalities have been described in this article are multiple evanescent white dot syndrome, acute posterior multifocal placoid pigment epitheliopathy, acute zonal occult outer retinopathy, multifocal choroiditis and panuveitis, punctate inner choroidopathy, serpiginous choroiditis, and birdshot chorioretinopathy. The various imaging modalities help us to better understand the pathophysiology of the various entities and help in diagnosing, monitoring, and prognosticating them.
View Article and Find Full Text PDFOcul Immunol Inflamm
December 2024
School of Medicine, Dentistry and Biomedical Sciences, Queens Belfast University, Belfast, UK.
Purpose: To present a case of indolent, nonprogressive multifocal choroidal lesions and contribute to the limited reports aiding this diagnosis, supplemented by a review of the literature.
Methods: Clinical records of a patient were reviewed alongside relevant literature from PubMed, Cochrane, and Google Scholar.
Results: A male in late 50s presented with a 10-year history of unilateral yellow-white asymptomatic fundus lesions in the left eye.
Invest Ophthalmol Vis Sci
November 2024
Université Paris Cité, Centre d'ophtalmologie de l'Assistance Publique, Hôpitaux de Paris, Paris, France.
Purpose: HLA-A29 is the main susceptibility factor for birdshot chorioretinitis (BSCR). Our study assessed the impact of the second HLA-A allele alongside HLA-A29 on BSCR severity and susceptibility, focusing on HLA-A29 homozygous patients and those with alleles from the HLA-Aw19 group.
Methods: We included 120 additional cases to our previous analysis of 286 patients with BSCR, all HLA-A29 positive.
Retina
October 2024
Department of Ophthalmology, Reference Center for Rare Diseases, Pitié-Salpêtrière Hospital, Paris-Sorbonne University, Paris, France.
Purpose: To assess the long-term efficacy and safety of treatments for cystoid macular edema in birdshot retinochoroïditis.
Methods: Observational retrospective study of 142 HLA-A29-positive patients with cystoid macular edema; the main outcome was the optical coherence tomography intraretinal cysts resolution.
Results: During the mean follow-up of 75 months (12-178), 61.
J Clin Med
August 2024
Department of Ophthalmology, Medical University of Lodz, 90-153 Lodz, Poland.
A 54-year-old, one-eyed Caucasian male was admitted to the Ophthalmology Clinic due to a gradual deterioration of vision in the right eye for approximately two weeks. The patient denied any trauma or viral infection during this time. On the day of admission, the patient's best corrected visual acuity (BCVA) in the right eye was 0.
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