AI Article Synopsis
- Musculoskeletal sarcomas are tough cancers that usually affect kids and teenagers, and they can happen in bones and soft tissues.
- New treatments called HDAC inhibitors (like MC1742 and MC2625) can help fight these cancer stem cells, which are really hard to kill.
- The treatment made the cancer cells stop growing and even helped some cells turn into bone cells without being harmful, and more tests will be done to see how well it works in future experiments.
Article Abstract
Musculoskeletal sarcomas are aggressive malignancies of bone and soft tissues often affecting children and adolescents. Histone deacetylase inhibitors (HDACi) have been proposed to counteract cancer stem cells (CSCs) in solid neoplasms. When tested in human osteosarcoma, rhabdomyosarcoma, and Ewing's sarcoma stem cells, the new HDACi MC1742 (1) and MC2625 (2) increased acetyl-H3 and acetyl-tubulin levels and inhibited CSC growth by apoptosis induction. At nontoxic doses, 1 promoted osteogenic differentiation. Further investigation with 1 will be done in preclinical sarcoma models.
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| http://dx.doi.org/10.1021/acs.jmedchem.5b00126 | DOI Listing |
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