AI Article Synopsis
- MZF1 is a member of the SCAN-ZF transcription factor family, recently linked to various cancers, including leukemia and major solid tumors like lung, cervical, breast, and colorectal cancer.
- Despite its initial focus on myeloid differentiation, current research highlights its broader role in cancer development.
- The text examines how MZF1 is regulated in cancer through mechanisms like phosphorylation and sumoylation, the formation of nuclear bodies, and its interactions with co-activators and co-repressors.
Article Abstract
Myeloid zinc finger 1 (MZF1) belongs to the SCAN-Zinc Finger (SCAN-ZF) transcription factor family that has recently been implicated in a number of types of cancer. Although the initial studies concentrated on the role of MZF1 in myeloid differentiation and leukemia, the factor now appears to be involved in the etiology of major solid tumors such as lung, cervical, breast, and colorectal cancer. Here we discuss the regulation of MZF1 that mediated its recruitment and activation in cancer, concentrating on posttranslational modification by phosphorylation, and sumoylation, formation of promyelocytic leukemia nuclear bodies and its association with co-activators and co-repressors.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7380561 | PMC |
| http://dx.doi.org/10.1002/jcb.25203 | DOI Listing |
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