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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4443346 | PMC |
| http://dx.doi.org/10.1073/pnas.1505119112 | DOI Listing |
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View Article and Find Full Text PDFA randomized placebo-controlled clinical trial of the effectiveness of thyroxine and triiodothyronine and short-term exposure to bright light in prevention of decrements in cognitive performance and mood during prolonged Antarctic residence.
Clin Endocrinol (Oxf)
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School of Social Work and Departments of Anthropology and Preventive Medicine, University of Southern California, Los Angeles, CA 90089-0411, USA.
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School of Social Work and Department of Anthropology, University of Southern California, Los Angeles 90089-0411, USA.
Objectives: We previously reported that cognitive function improves with thyroxine and that there is a circannual pattern to mood and human TSH during Antarctic residence. To extend these findings, we examined the effects of tyrosine and a combined levothyroxine/liothyronine supplement in euthyroid men and women who spent the austral summer (n = 43) and/or winter (n = 42) in Antarctica.
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School of Social Work, University of Southern California, 669 W. 34th Street, Los Angeles CA, 90089-0411, USA.
We examined the physiological and psychological status of men and women who spent the summer (n=100) and/or winter (n=85) seasons in Antarctica at McMurdo (latitude 78.48 S, elevation 12 m) and South Pole (latitude 90 S, elevation 3880 m) stations to determine whether there were any significant differences by severity of the stations' physical environment. Physiological measures (body mass index, blood pressure, heart rate, tympanic temperature), serum measures of thyroid hormones, cortisol, and lipids and plasma catecholamines were obtained at predeployment (Sep-Oct) and the beginning of the summer (November) and winter (Mar-Apr) seasons.
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