Introduction: There is an ongoing debate about the existence and effects of Helicobacter pylori (Hp) in adenotonsillar tissue.
Objective: A clinical study was conducted to assess the existence of Hp in the adenoid and/or adenotonsillar tissues, which were surgically excised due to chronic adenotonsillitis.
Methods: Phosphoglucosamine mutase gene for the detection of Hp and cytotoxin-associated gene as virulence gene were examined in 84 adenotonsillar tissues obtained from 64 patients and patients' serum by using polymerase chain reaction.
Results: Hp IgG was detected in 57 (89%) patients' serum. A total of seven tissue samples from 64 patients (10.9%) were found positive for Hp DNA, of which five were adenoids and two were tonsil tissues. All polymerase chain reaction positive samples were also positive for the cytotoxin-associated gene, which is a virulence determinant for the organism.
Conclusion: This study suggests that children are exposed to Hp at an early age of their life in this province. Hp may have a role in the pathogenesis of chronic adenotonsillitis, especially in endemic areas.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9452227 | PMC |
http://dx.doi.org/10.1016/j.bjorl.2014.08.018 | DOI Listing |
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