AI Article Synopsis
- The study uses a mathematical model to explore how different types of antibodies affect HIV-1 infection during various stages of the disease.
- Neutralizing antibodies are most effective early in the infection after seroconversion, while antibodies that target infected cells are better once the infection is established.
- The model's findings, based on data from a study in Botswana, indicate that neutralizing antibodies are more efficient than other antibody types in controlling viral levels early in HIV infection.
Article Abstract
The role of antibodies in HIV-1 infection is investigated using a discrete-time mathematical model that considers cell-free and cell-associated transmission of the virus. Model analysis shows that the effect of each type of antibody is dependent on the stage of the infection. Neutralizing antibodies are efficient in controlling the viral levels in the early days after seroconversion and antibodies that coat HIV-1-infected cells and recruit effector cells to either kill the HIV-1-infected cells or inhibit viral replication are efficient when the infection becomes established. Model simulations show that antibodies that inhibit viral replication are more effective in controlling the infection than those that recruit Natural Killer T cells after infection establishment. The model was fitted to subjects of the Tsedimoso study conducted in Botswana and conclusions similar to elasticity analysis results were obtained. Model fitting results predicted that neutralizing antibodies are more efficient in controlling the viral levels than antibodies that coat HIV-1-infected cells and recruit effector cells to either kill the HIV-1-infected cells or inhibit viral replication in the early days after seroconversion.
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| http://dx.doi.org/10.1093/imammb/dqv014 | DOI Listing |
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