Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1097/JTO.0000000000000386 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The limbic and extra-limbic encephalitis associated with glutamic acid decarboxylase (GAD)-65 antibodies: an observational study.
Neurol Sci
December 2024
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510000, China.
We aimed to define the clinical features and outcomes of encephalitis associated with anti-GAD65 Abs. In addition, we reviewed cases published in the literature with GAD65 encephalitis. We retrospectively studied 482 consecutive patients attending a tertiary care center for evaluation of an autoimmune neurological disorder.
View Article and Find Full Text PDFAnti-Tr/DNER Antibody-associated Paraneoplastic Neurological Syndrome Presenting Limbic Encephalitis with Anaplastic Large Cell Lymphoma: A Case Report.
Intern Med
December 2024
Department of Neurology, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Japan.
An 82-year-old man presented with acute progressive disturbance of consciousness. We suspected autoimmune limbic encephalitis because of abnormal magnetic resonance imaging findings in the bilateral temporal lobes and cerebrospinal fluid pleocytosis. The patient tested positive for anti-Tr/Delta/Notch-like epidermal growth factor-related receptor (DNER) antibodies, and a tissue biopsy revealed complications of anaplastic large cell lymphoma.
View Article and Find Full Text PDFLong term survival and outcomes in patients with paraneoplastic neurologic syndromes.
Front Immunol
December 2024
Department of Neurology, Rambam HealthCare Campus, Haifa, Israel.
Objective: It is unknown whether delay in diagnosis affects morbidity reportedly in paraneoplastic syndromes (PNS). We aimed to explore various aspects of PNS, including prevalence, clinical characteristics, diagnostic criteria, and treatment outcomes.
Methods: We studied n-PNS diagnosis between 2016 to 2023, and included only patients with positive onconeural antibodies, who developed cancer, and exhibited a recognizable PNS phenotype.
In recent years, there has been an increasing number of studies on neurological symptoms induced as paraneoplastic neurological syndrome (PNS) or neurological immune-related adverse events (irAEs) in patients treated with immune checkpoint inhibitors (ICIs). Herein, we report a 68-year-old male patient with small-cell lung cancer who developed memory impairment and autonomic nervous system dysfunction after three courses of carboplatin, etoposide, and durvalumab therapy. Brain magnetic resonance imaging revealed hyperintense areas restricted to the bilateral temporal lobes.
View Article and Find Full Text PDFImmune-mediated neurological syndromes associated with childhood cancers.
Eur J Paediatr Neurol
November 2024
Children's Neurosciences, Evelina London Children's Hospital at Guy's and St Thomas' NHS Foundation Trust, London, United Kingdom; Department Women and Children's Health, School of Life Course Sciences (SoLCS), King's College, London, United Kingdom. Electronic address:
Article Synopsis
- The review discusses the link between neurological conditions and underlying cancers, focusing on genetic, environmental, and tumor-related factors that can lead to autoimmunity and paraneoplastic syndromes.
- It covers the pathogenesis of specific paraneoplastic conditions in children, such as Opsoclonus myoclonus ataxia syndrome and NMDA receptor encephalitis, along with current treatment strategies.
- The text highlights advancements in cancer therapies, particularly immune treatments, and examines their potential neurological side effects, emphasizing the need to balance risks and benefits.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!