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Vitamin D deficiency in early pregnancy. | LitMetric

Vitamin D deficiency in early pregnancy.

PLoS One

Department of Clinical Investigation, Madigan Army Medical Center, Joint Base Lewis-McChord, Tacoma, Washington, United States of America.

Published: April 2016

AI Article Synopsis

  • Vitamin D deficiency is common among reproductive-aged women in the U.S. and may affect pregnancy outcomes, prompting this study to investigate its relationship during the first trimester.
  • A retrospective analysis of plasma from 310 women revealed that 70% were vitamin D insufficient, but statistical analysis showed no significant link between vitamin D levels and adverse pregnancy outcomes like preeclampsia or gestational diabetes.
  • The study concluded that while vitamin D deficiency did not correlate with negative pregnancy results, it still indicates a widespread issue among young women that warrants further attention.

Article Abstract

Objective: Vitamin D deficiency is a common problem in reproductive-aged women in the United States. The effect of vitamin D deficiency in pregnancy is unknown, but has been associated with adverse pregnancy outcomes. The objective of this study was to analyze the relationship between vitamin D deficiency in the first trimester and subsequent clinical outcomes.

Study Design: This is a retrospective cohort study. Plasma was collected in the first trimester from 310 nulliparous women with singleton gestations without significant medical problems. Competitive enzymatic vitamin D assays were performed on banked plasma specimens and pregnancy outcomes were collected after delivery. Logistic regression was performed on patients stratified by plasma vitamin D concentration and the following combined clinical outcomes: preeclampsia, preterm delivery, intrauterine growth restriction, gestational diabetes, and spontaneous abortion.

Results: Vitamin D concentrations were obtained from 235 patients (mean age 24.3 years, range 18-40 years). Seventy percent of our study population was vitamin D insufficient with a serum concentration less than 30 ng/mL (mean serum concentration 27.6 ng/mL, range 13-71.6 ng/mL). Logistic regression was performed adjusting for age, race, body mass index, tobacco use, and time of year. Adverse pregnancy outcomes included preeclampsia, growth restriction, preterm delivery, gestational diabetes, and spontaneous abortion. There was no association between vitamin D deficiency and composite adverse pregnancy outcomes with an adjusted odds ratio of 1.01 (p value 0.738, 95% confidence intervals 0.961-1.057).

Conclusion: Vitamin D deficiency did not associate with adverse pregnancy outcomes in this study population. However, the high percentage of affected individuals highlights the prevalence of vitamin D deficiency in young, reproductive-aged women.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4405493PMC
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0123763PLOS

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