Introduction: The relation between objectively measured physical activity (PA) and metabolic and cardiovascular risk factors has not been studied in Iceland. This study aimed to investigate PA and metabolic and cardiovascular risk factors among three professions: manual laborers, office workers, and farmers.
Material And Methods: The participants (73 males, 89 females) underwent anthropometric measurements. Total PA and time spent in moderate-to-vigorous PA (MVPA) was assessed with activity monitors. Blood pressure was measured and fasting blood samples analyzed for total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, glucose, insulin and homeostatic model assessment.
Results: Male manual laborers and farmers were more physically active than office workers (p<0.01), but no difference was found among females. Nevertheless, female farmers spent less time in MVPA than other professions (p%lt;0.05). Low proportion (18.4%) of all participants and none of the male office workers met the guidelines of the Directorate of Health for daily PA. Farmers had lower levels of triglycerides (p=0.01) and glucose (p<0.01), and greater fat-free mass (p<0.03) than other professions. They also had the highest levels of high-density lipoprotein cholesterol, followed by manual laborers, and then office workers (p<0.02). Total PA was significantly related to a greater number of metabolic risk factors than time spent in MVPA.
Conclusion: Farmers have the most favorable metabolic and cardiovascular risk factors in the blood and their PA and fat-free mass are a likely explanation. Regardless, their PA is low, and only one-fifth of all participants meet the guidelines for daily PA. Total PA appears more important for the metabolic and cardiovascular risk factors than time spent in MVPA.
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http://dx.doi.org/10.17992/lbl.2015.04.21 | DOI Listing |
BMC Pharmacol Toxicol
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Department of Pharmaceutics and Pharmaceutical Technology, Kampala International University, Western Campus, P.O. Box 71, Ishaka - Bushenyi, Uganda.
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Human Health Therapeutics Research Centre, National Research Council Canada, Ottawa, ON, Canada.
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View Article and Find Full Text PDFJ Neuroinflammation
January 2025
Department of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
The thrombolytic protease tissue plasminogen activator (tPA) is expressed in the CNS, where it regulates diverse functions including neuronal plasticity, neuroinflammation, and blood-brain-barrier integrity. However, its role in different brain regions such as the substantia nigra (SN) is largely unexplored. In this study, we characterize tPA expression, activity, and localization in the SN using a combination of retrograde tracing and β-galactosidase tPA reporter mice.
View Article and Find Full Text PDFEur J Med Res
January 2025
Medical Big Data Research Center, Medical Innovation Research Division, Chinese PLA General Hospital, 28 Fuxing RD., Beijing, 100853, China.
Background: Chronic kidney disease (CKD) carries the highest population attributable risk for mortality among all comorbidities in chronic heart failure (CHF). No studies about the association between inferior vena cava (IVC) diameter and all-cause mortality in patients with the comorbidity of CKD and CHF has been published.
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Mol Cancer
January 2025
Department of Medical and Surgical Sciences for Children and Adults, University of Modena and Reggio Emilia, via Campi, 287, Modena, 41125, Italy.
B cells have emerged as central players in the tumor microenvironment (TME) of non-small cell lung cancer (NSCLC). However, although there is clear evidence for their involvement in cancer immunity, scanty data exist on the characterization of B cell phenotypes, bioenergetic profiles and possible interactions with T cells in the context of NSCLC. In this study, using polychromatic flow cytometry, mass cytometry, and spatial transcriptomics we explored the intricate landscape of B cell phenotypes, bioenergetics, and their interaction with T cells in NSCLC.
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