AI Article Synopsis
- Biomimetic calcium phosphate coatings are designed for bone regeneration due to their compatibility with the body, ability to support bone cell growth, and simple production process.
- Incorporating agents like BMP-2 into these coatings allows for a controlled release, promoting sustained bone formation as the coating degrades in response to specific cells like osteoclasts.
- The review also discusses preparation methods, properties, and pre-clinical uses of these coatings, while comparing them to hydroxyapatite coatings to highlight future clinical applications.
Article Abstract
Biomimetic calcium phosphate coatings have been developed for bone regeneration and repair because of their biocompatibility, osteoconductivity, and easy preparation. They can be rendered osteoinductive by incorporating an osteogenic agent, such as bone morphogenetic protein 2 (BMP-2), into the crystalline lattice work in physiological situations. The biomimetic calcium phosphate coating enables a controlled, slow and local release of BMP-2 when it undergoes cell mediated coating degradation induced by multinuclear cells, such as osteoclasts and foreign body giant cells, which mimics a physiologically similar release mode, to achieve sustained ectopic or orthotopic bone formation. Therefore, biomimetic calcium phosphate coatings are considered to be a promising delivery vehicle for osteogenic agents. In this review, we present an overview of biomimetic calcium phosphate coatings including their preparation techniques, physico-chemical properties, potential as drug carrier, and their pre-clinical application both in ectopic and orthotopic animal models. We briefly review some features of hydroxyapatite coatings and their clinical applications to gain insight into the clinical applications of biomimetic calcium phosphate coatings in the near future.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4391212 | PMC |
| http://dx.doi.org/10.2174/1874120701509010056 | DOI Listing |
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