This report presents a new case of mucormycosis encountered in penguin characterized by morphological variation of hyphae and presence of sporangia with numerous sporangiospores. A 4.5-year-old Magellanic penguin (Spheniscus magellanicus) died after exhibiting anorexia, poor nutritional condition and dyspnea. Multiple nodular lesions were observed in the thoracic and abdominal regions. Histopathologically, hyphae of various sizes were seen in the lungs, air sac and nodular lesions. Myriad sporangiospores and several sporangia were observed in/around the bronchi or parabronchi. The very narrow and short hyphae in the nodules were not consistent with the characteristics of Mucorales. However, for most hyphae, including those in the nodules, sporangiospores and sporangia, immunohistochemistry revealed Mucorales-positive reactions. In addition, these fungi were identified as Rhizomucor pusillus by gene analysis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4565808 | PMC |
| http://dx.doi.org/10.1292/jvms.14-0527 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Application of Metagenomics Next-Generation Sequencing on Diagnosis of Disseminated Infection Caused by in an Acute Lymphoblastic Leukemia Patient.
Infect Drug Resist
December 2024
Department of Clinical Laboratory, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, People's Republic of China.
Background: is one of the major pathogens in mucormycosis. Infection due to is rare and has a high mortality rate, especially disseminated mucormycosis infections. Rapid and accurate pathogen identification is important for the development of targeted antifungal therapies.
View Article and Find Full Text PDFRepurposing the non-steroidal anti-inflammatory drug diflunisal as an adjunct therapy with amphotericin B against mucoralean fungi.
J Med Microbiol
November 2024
Department of Microbial Biotechnology, Panjab University, Chandigarh 160014, India.
Mucormycosis is an aggressive, angioinvasive infection associated with high morbidity and mortality. The disease remains difficult to treat, with limited available antifungal drugs. Consequently, there is an urgent need to develop alternate therapeutics against mucormycosis.
View Article and Find Full Text PDFSubchronic Toxicity Evaluation of Dietary Administration of a Fungal Biomass From Rhizomucor pusillus.
J Appl Toxicol
October 2024
Charles River Laboratories Hungary Kft., Veszprém, Hungary.
Article Synopsis
- Fungal food products, particularly from the strain Rhizomucor pusillus CBS 143028, are seen as sustainable and nutritious options for consumers, with the potential to enhance food supply sustainability.
- The fermentation of R. pusillus CBS 143028 produces a mycelium biomass rich in proteins, micronutrients, and cell wall components, but it is classified as a novel food which necessitates a safety assessment.
- A 90-day toxicity study on Wistar rats showed no biologically relevant adverse effects from high doses of R. pusillus mycelium, leading to a no-observed-adverse-effect level (NOAEL) established at 300,000 ppm.
Epidemiology and prognostic factors of mucormycosis in France (2012-2022): a cross-sectional study nested in a prospective surveillance programme.
Lancet Reg Health Eur
October 2024
Institut Pasteur, Paris Cité University, National Reference Center for Invasives Mycoses and Antifungals, Mycology Department, Paris, France.
Article Synopsis
- Mucormycosis, a severe fungal infection highlighted by the WHO, was studied in France from 2012 to 2022, revealing significant trends in epidemiology and mortality factors.
- Out of 550 cases, key underlying conditions included hematological malignancies (65.1%), with pulmonary infections most common (52.4%) and substantial seasonal variations suggesting more cases in autumn.
- The study linked the rise in PCR diagnostic methods to improved patient outcomes, highlighting that age, ICU diagnosis, and hematological malignancies increased mortality, while diagnosis after 2015 and surgical interventions decreased it.
Clinical features of pediatric mucormycosis: role of metagenomic next generation sequencing in diagnosis.
Front Cell Infect Microbiol
June 2024
Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China.
Background: Mucormycosis is an uncommon invasive fungal infection that has a high mortality rate in patients with severe underlying diseases, which leads to immunosuppression. Due to its rarity, determining the incidence and optimal treatment methods for mucormycosis in children is challenging. Metagenomic next-generation sequencing (mNGS) is a rapid, precise and sensitive method for pathogen detection, which helps in the early diagnosis and intervention of mucormycosis in children.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!